Effects of endocrine disrupting chemicals in host health: Three-way interactions between environmental exposure, host phenotypic responses, and gut microbiota.
Effects of endocrine disrupting chemicals in host health: Three-way interactions between environmental exposure, host phenotypic responses, and gut microbiota.
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DOI：
10.1016/j.envpol.2020.116387
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发表时间：
2020-12
影响因子：
8.9
通讯作者：
Na Li;Jinhua Li;Qingqing Zhang;Shenshen Gao;Xu Quan;Ping Liu;Chundi Xu
中科院分区：
文献类型：
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作者：
Na Li;Jinhua Li;Qingqing Zhang;Shenshen Gao;Xu Quan;Ping Liu;Chundi Xu
近几十年来，内分泌干扰物（EDCs）逐渐成为全球性的健康危害。肠道菌群（GM）是环境和人体之间的重要接口。EDCs暴露、宿主表型背景和转基因效应之间可能存在三位一体关系。在这篇综述中，我们试图分析转基因对EDCs诱导的宿主表型反应改变的贡献，提示转基因干预可能被用作限制病原体扩张的治疗策略。这些研究可以增加对致病机制的理解，并有助于确定潜在疾病易感性人群中可改变的环境因素和微生物群特征，以便进行预防和补救。
Endocrine disrupting chemicals (EDCs) have gradually become a global health hazard in recent decades. Gut microbiota (GM) provides a crucial interface between the environment and the human body. A triad relationship may exist between EDCs exposure, host phenotypic background, and GM effects. In this review, we attempted to parse out the contribution of GM on the alteration of host phenotypic responses induced by EDCs, suggesting that GM intervention may be used as a therapeutic strategy to limit the expansion of pathogen. These studies can increase the understanding of pathogenic mechanisms, and help to identify the modifiable environmental factors and microbiota characteristics in people with underlying disease susceptibility for prevention and remediation.