Evidence for the Transmission of Plasmodium vivax in the Republic of the Congo, West Central Africa
Evidence for the Transmission of Plasmodium vivax in the Republic of the Congo, West Central Africa
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DOI：
10.1086/644510
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发表时间：
2009-11-01
影响因子：
6.4
通讯作者：
Tanabe, Kazuyuki
中科院分区：
文献类型：
--
作者：
Culleton, Richard;Ndounga, Mathieu;Tanabe, Kazuyuki
间日疟原虫被认为不会在西非和中非传播，因为当地人群中红细胞达菲阴性表型非常普遍，这种情况被认为赋予了对间日疟原虫血液感染的完全抗性。然而，不断有从该地区返回的旅行者感染间日疟原虫的报告。为了调查该地区是否发生传播，在刚果共和国的个体中评估了间日疟原虫红细胞前期抗原特异性抗体的存在。酶联免疫吸附法检测的409份样本中，有55份（13%）具有间日疟原虫特异性抗原的抗体。
Plasmodium vivax is not thought to be transmitted in western and central Africa, because of the very high prevalence of the red blood cell Duffy-negative phenotype in local populations, a condition which is thought to confer complete resistance against blood infection with P. vivax. There are, however, persistent reports of travelers returning from this region with P. vivax infections. To investigate whether transmission occurs in this region, the presence of antibodies specific to P. vivax preerythrocytic-stage antigens was assessed in individuals from the Republic of the Congo. A total of 55 (13%) of 409 samples tested by enzyme-linked immunosorbent assay had antibodies to P. vivax-specific antigens.