Repeated high-frequency transcranial magnetic stimulation over the dorsolateral prefrontal cortex reduces cigarette craving and consumption
Repeated high-frequency transcranial magnetic stimulation over the dorsolateral prefrontal cortex reduces cigarette craving and consumption
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DOI：
10.1111/j.1360-0443.2008.02448.x
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发表时间：
2009-04-01
期刊：
影响因子：
6
通讯作者：
Zangen, Abraham
中科院分区：
文献类型：
--
作者：
Amiaz, Revital;Levy, Dino;Zangen, Abraham
为评价重复高频经颅磁刺激（rTMS）左背外侧前额叶皮层（DLPFC）结合吸烟或中性线索对吸烟、依赖和渴求的影响，将被试随机分为真实的刺激组和假刺激组。每组被随机分为两个亚组，在每日TMS干预之前提供与吸烟相关或中性的图片。每天10次rTMS会议，每个工作日，然后进行维持阶段，其中rTMS会议不太频繁。单点，门诊，随机，双盲，假对照。48名慢性吸烟者每天吸烟至少20支，并有动机戒烟。通过报纸和互联网上的广告从普通人群中招募健康的男性和女性，在DLPFC上使用标准的8字形线圈进行10次每日rTMS治疗。刺激包括在100%运动阈值下20次训练/天。每列由50个10赫兹的脉冲组成，每列之间的间隔为15秒。香烟消费量通过测量尿样中的可替宁水平进行客观评估，并通过参与者的自我报告进行主观评估。通过标准问卷调查评估依赖性和渴望性，在DLPFC上每天进行10次rTMS治疗可以减少吸烟量和尼古丁依赖。此外，治疗阻断了由每天呈现与吸烟相关的图片引起的渴望。然而，这些效应往往会随着时间的推移而消失。多次高频rTMS的DLPFC可以减弱尼古丁的渴望。
To evaluate the effect of repeated high-frequency transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC), combined with either smoking or neutral cues, on cigarette consumption, dependence and craving.Participants were divided randomly to real and sham stimulation groups. Each group was subdivided randomly into two subgroups presented with either smoking-related or neutral pictures just before the daily TMS intervention. Ten daily rTMS sessions were applied every week-day and then a maintenance phase was conducted in which rTMS sessions were less frequent.Single-site, out-patient, randomized, double-blind, sham-controlled.Forty-eight chronic smokers who smoked at least 20 cigarettes per day and were motivated to quit smoking. Healthy males and females were recruited from the general population using advertisements in newspapers and on internet websites.Ten daily rTMS sessions were administered using a standard figure-8 coil over the DLPFC. Stimulation included 20 trains/day at 100% of motor threshold. Each train consisted of 50 pulses at 10 Hz with an inter-train interval of 15 seconds.Cigarette consumption was evaluated objectively by measuring cotinine levels in urine samples and subjectively by participants' self-reports. Dependence and craving were evaluated by standard questionnaires.Ten daily rTMS sessions over the DLPFC reduced cigarette consumption and nicotine dependence. Furthermore, treatment blocked the craving induced by daily presentation of smoking-related pictures. However, these effects tended to dissipate over time.Multiple high-frequency rTMS of the DLPFC can attenuate nicotine craving.