Continuous association of total bile acid levels with the risk of small for gestational age infants
Continuous association of total bile acid levels with the risk of small for gestational age infants
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总胆汁酸水平与小于胎龄儿的风险持续相关
DOI：
10.1038/s41598-020-66138-y
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发表时间：
2020-06-09
影响因子：
4.6
通讯作者：
Chen，Yuan Hua
中科院分区：
文献类型：
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作者：
Li，Li;Chen，Wei;Chen，Yuan Hua
母体血清总胆汁酸（TBA）水平与小于胎龄儿（SGA）之间的关系尚不清楚。我们调查了中国人群中不同程度的血清TBA水平与SGA婴儿风险之间的关系。本研究对11811例单胎妊娠的母亲进行了队列研究。受试者根据母体血清TBA水平分为七类。有趣的是，出生大小减少，而SGA婴儿的比率在血清TBA类别增加的情况下增加。与分类1相比，SGA婴儿的校正OR（95%CI）为0.99（0.82-1.21）第2类，1.22（0.97-1.53）第3类，1.99（1.53-2.58），5类2.91（2.16-3.93），6类4.29（3.33-5.54），7类9.01（5.99-13.53）。此外，SGA婴儿血清TBA水平每增加1-SD的校正OR（95%CI）在所有受试者中分别为1.36（1.29-1.43），在无胆汁淤积受试者中为2.40（1.82-3.45），在有胆汁淤积受试者中为1.13（1.06-1.22）。这些结果表明，妊娠期胆汁淤积症增加了SGA婴儿的风险。此外，我们的研究结果表明，血清TBA水平低于胆汁淤积症的诊断水平与出生体重减少和SGA婴儿风险增加有强烈的持续相关性。
The association between maternal serum total bile acid (TBA) levels and small-for-gestational-age (SGA) infants is unclear. We investigated the association between various degrees of serum TBA levels and the risk of SGA infants in a Chinese population. The current study performed a cohort study among 11811 mothers with singleton pregnancy. Subjects were divided into seven categories according to maternal serum TBA levels. Interestingly, birth sizes were reduced, whereas the rate of SGA infants was increased across increasing categories of serum TBA. Compared to category 1, adjusted ORs (95%CI) for SGA infants were 0.99 (0.82–1.21) in category 2, 1.22 (0.97–1.53) in category 3, 1.99 (1.53–2.58) in category 4, 2.91 (2.16–3.93) in category 5, 4.29 (3.33–5.54) in category 6, and 9.01 (5.99–13.53) in category 7, respectively. Furthermore, adjusted ORs (95%CI) for SGA infants for each 1-SD increase in serum TBA levels were 1.36 (1.29–1.43) among all subjects, 2.40 (1.82–3.45) among subjects without cholestasis, and 1.13 (1.06–1.22) among subjects with cholestasis, respectively. These results suggest that gestational cholestasis increases the risk of SGA infants. Additionally, our results indicate strong, continuous associations of serum TBA levels below those diagnostic of cholestasis with a decreased birth sizes and an increased risk of SGA infants.