Amygdala to hippocampal volume ratio is associated with negative memory bias in healthy subjects
Amygdala to hippocampal volume ratio is associated with negative memory bias in healthy subjects
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DOI：
10.1017/s003329171100122x
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发表时间：
2012-02-01
影响因子：
6.9
通讯作者：
Tendolkar, I.
中科院分区：
文献类型：
--
作者：
Gerritsen, L.;Rijpkema, M.;Tendolkar, I.
背景负性记忆偏差被认为是抑郁症的主要认知风险和维持因素之一，但其神经基础在很大程度上是未知的。在这里，我们研究了记忆偏差是否与杏仁核和海马体积有关，这两个结构对情绪记忆过程至关重要，并且在抑郁症中表现出一致的体积变化。对272名健康参与者（62%女性，18-50岁）进行了结构磁共振成像（MRI）。所有图像均在1.5T Siemens MRI扫描仪上采集。使用FSL的FIRST模块对杏仁核和海马进行自动分割。采用自我指涉编码/评价测验评定负性记忆偏向。负记忆偏差与较大的杏仁核（p = 0.042）和较小的海马（p = 0.029）体积相关。在额外的分析中，我们发现，与海马体和杏仁核体积分别发现的关联相比，负性记忆偏差与杏仁核：海马体体积比之间的关联更强（p = 0.021）。在非抑郁的受试者中，我们发现较大的杏仁核和较小的海马体积与负记忆偏差有关。这表明杏仁核：海马体积比的增加在抑郁症高危人群中常见的认知脆弱性中起作用，并且这些结构性大脑差异可能早于抑郁症的发作。收稿日期：2011年1月23日;修订日期：2011年6月15日;接受日期：2011年6月15日;首次在线发表日期：2011年7月11日
Background. Negative memory bias is thought to be one of the main cognitive risk and maintenance factors for depression, but its neural substrates are largely unknown. Here, we studied whether memory bias is related to amygdala and hippocampal volume, two structures that are critical for emotional memory processes and that show consistent volume alterations in depression.Method. Structural magnetic resonance imaging (MRI) was carried out in 272 healthy participants (62% female, 18-50 years old). All images were acquired on 1.5 T Siemens MRI scanners. Automatic segmentation of amygdala and hippocampus was performed using the FIRST module of FSL. Negative memory bias was assessed by the self-referent encoding/evaluation test.Results. Negative memory bias was associated with larger amygdala (p = 0.042) and smaller hippocampal (p = 0.029) volumes. In additional analyses, we found that, compared with the associations found with hippocampus and amygdala volume separately, a stronger association was found between negative memory bias and the ratio of amygdala: hippocampus volume (p = 0.021).Conclusions. In non-depressed subjects we found that larger amygdala and smaller hippocampal volumes are associated with negative memory bias. This suggests that an increased amygdala: hippocampus volume ratio plays a role in cognitive vulnerability often seen in individuals with high risk for depression and that these structural brain differences may pre-date the onset of depression. Received 23 January 2011; Revised 15 June 2011; Accepted 15 June 2011; First published online 11 July 2011