Comparative MHC nomenclature: report from the ISAG/IUIS-VIC committee 2018
Comparative MHC nomenclature: report from the ISAG/IUIS-VIC committee 2018
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DOI：
10.1007/s00251-018-1073-3
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发表时间：
2018-11-01
期刊：
影响因子：
3.2
通讯作者：
Marsh, Steven G. E.
中科院分区：
文献类型：
--
作者：
Ballingall, Keith T.;Bontrop, Ronald E.;Marsh, Steven G. E.
在过去的十年里，在确定许多非人类物种的核苷酸、等位基因、单倍型、双倍型和群体水平的主要组织相容性复合体(MHC)多样性方面取得了重大进展。这一进展在很大程度上是由与核苷酸测序技术相关的可用性的增加和成本的降低推动的。本报告介绍了比较MHC命名委员会的最新活动，该委员会是国际动物遗传学学会(ISAG)和国际免疫学会联合会(IUIS)的常设委员会，在兽医免疫学委员会(VIC)的保护伞下运作。该委员会2006年的前一份报告明确了该委员会在为非人类物种MHC基因座的基因和等位基因制定标准化命名法方面的作用。它描述了免疫多态数据库IPD-MHC的建立，该数据库继续向公众提供对一系列物种的高质量MHC序列数据的访问。在本报告中，描述了继续制定通用MHC命名框架的指导方针，总结了IPD-MHC项目中各物种部分的持续发展情况。
Significant progress has been made over the last decade in defining major histocompatibility complex (MHC) diversity at the nucleotide, allele, haplotype, diplotype, and population levels in many non-human species. Much of this progress has been driven by the increased availability and reduced costs associated with nucleotide sequencing technologies. This report provides an update on the activities of the comparative MHC nomenclature committee which is a standing committee of both the International Society for Animal Genetics (ISAG) and the International Union of Immunological Societies (IUIS) where it operates under the umbrella of the Veterinary Immunology Committee (VIC). A previous report from this committee in 2006 defined the role of the committee in providing guidance in the development of a standardized nomenclature for genes and alleles at MHC loci in non-human species. It described the establishment of the Immuno Polymorphism Database, IPD-MHC, which continues to provide public access to high quality MHC sequence data across a range of species. In this report, guidelines for the continued development of a universal MHC nomenclature framework are described, summarizing the continued development of each species section within the IPD-MHC project.