Advances of Regulatory B Cells in Autoimmune Diseases.

Advances of Regulatory B Cells in Autoimmune Diseases.
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调节性B细胞在自身免疫性疾病中的研究进展

DOI:
10.3389/fimmu.2021.592914
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发表时间:
2021
影响因子:
7.3
通讯作者:
Tian J
Tian J
中科院分区:
医学2区
文献类型:
--
作者:
Zhu Q;Rui K;Wang S;Tian J

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With the ability to induce T cell activation and elicit humoral responses, B cells are generally considered as effectors of the immune system. However, the emergence of regulatory B cells (Bregs) has given new insight into the role of B cells in immune responses. Bregs exhibit immunosuppressive functions via diverse mechanisms, including the secretion of anti-inflammatory cytokines and direct cell contact. The balance between Bregs and effector B cells is important for the immune tolerance. In this review, we focus on recent advances in the characteristics of Bregs and their functional roles in autoimmunity.
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