TINU Syndrome Associated with Reduced Complement Levels
TINU Syndrome Associated with Reduced Complement Levels
复制标题
与补体水平降低相关的 TINU 综合征
DOI：
10.1159/000046096
复制
发表时间：
2001
期刊：
影响因子：
2.5
通讯作者：
P. A. Bevilacqua
中科院分区：
文献类型：
--
作者：
P. Conz;M. Milan;L. Bragantini;G. La Greca;P. A. Bevilacqua
TINU综合征（小管间质性肾炎和葡萄膜炎）最早由Dobrin等人于1975年描述。从那时起，已有50多例病例被记录在案，每个病例都具有不同的免疫病理和遗传特征。本报告的目的是描述一个与补体水平降低有关的TINU病例。我们分析了一位48岁的白人女性，她在病理急性期持续减少C4补体水平，但免疫特征没有改变。肾活检显示明显淋巴细胞间质浸润。间质浸润的免疫组化研究显示T （CD3）标记物（CD4 > CD8）的存在呈阳性。类固醇治疗使症状完全消退，补体水平恢复正常。我们认为，有可能假设与TINU相关的各种免疫改变，包括短暂的补体减少水平，可能是继发于在整个病理过程中表达自己的多种炎症机制。
The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels. We profile a 48-year-old white female with persistently reduced C4 complement levels during the acute phase of the pathology and with an unaltered immunologic profile. Renal biopsy evidenced a significant lymphocytic interstitial infiltration. Immunohistochemical studies of the interstitium infiltrates was positive for the presence of the T (CD3) markers (CD4 > CD8). Steroid therapy yielded a complete regression of the symptomatology with normalization of the complement levels. We suggest that it is possible to hypothesize that the various immunologic alterations associated with TINU, including the transient reduction complement levels, may be secondary to multiple inflammatory mechanisms which express themselves throughout the pathology.