Effects of Dopaminergic Agonists on Plasma Luteinizing Hormone - Releasing Hormone (LRH) and Gonadotropins in Man
Effects of Dopaminergic Agonists on Plasma Luteinizing Hormone - Releasing Hormone (LRH) and Gonadotropins in Man
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多巴胺能激动剂对人类血浆黄体生成素释放激素（LRH）和促性腺激素的影响
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
K. Nakagawa
中科院分区：
文献类型：
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作者：
M. Matsubara;M. Tango;K. Nakagawa
为探讨多巴胺（DA）对人体促性腺激素分泌的作用部位和方式，对19名健康志愿者（7名健康男性，5名卵泡期女性和7名绝经后女性）进行了4个系列的研究。以4 μ g/kg/min的速率静脉输注DA使血浆LH水平降至初始水平的75.9 +/- 3.7（平均值+/- SE）%。口服500 mg左旋多巴（Dopa）也可将血浆LH浓度抑制至73.0 +/-3.5%，但预处理两剂100 mg卡比多巴（CD）（一种外周多巴脱羧酶抑制剂）可减弱多巴对LH水平的抑制作用（最低值82.4 +/- 4.1）。这些药物对血浆FSH无显著影响。另一方面，外周血中内源性LRH的浓度在整个研究中保持不变。CD单独给药对这3个参数中的任何一个都没有影响。这些结果表明，DA对垂体促性腺激素细胞的直接抑制作用，虽然在下丘脑水平的调制也不能排除。
To try to determine the site and mode of action of dopamine (DA) on the secretion of gonadotropins in humans, 4 series of studies were performed in 19 healthy volunteers (7 healthy males, 5 females in follicular phase and 7 postmenopausal females). The intravenous infusion of DA at the rate of 4 micrograms/kg/min decreased plasma LH levels to 75.9 +/- 3.7 (mean +/- SE)% of the initial levels. The oral administration of 500 mg of levodopa (Dopa) also suppressed the concentration of plasma LH to 73.0 +/- 3.5%, but the pretreatment with two doses of 100 mg each of carbidopa (CD), a peripheral dopa decarboxylase inhibitor, attenuated this suppressing effect of Dopa on LH levels (nadir 82.4 +/- 4.1). Plasma FSH were not significantly altered by these drugs. On the other hand, the concentration of endogenous LRH in peripheral blood remained unchanged throughout the studies. The administration of CD alone had no effect on any of these 3 parameters. These results would suggest the direct suppressing effect of DA on pituitary gonadotrophs, although the modulation at the level of the hypothalamus also cannot be ruled out.