Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii.
Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii.
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来自冠突散囊菌 EN-220 的吲哚酮哌嗪生物碱，一种从海藻马尾藻中分离的内生真菌
DOI：
10.3390/md15020024
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发表时间：
2017-01-25
期刊：
影响因子：
5.4
通讯作者：
Wang BG
中科院分区：
文献类型：
--
作者：
Du FY;Li X;Li XM;Zhu LW;Wang BG
从海藻马尾藻En-220的培养提取物中分离鉴定了4个新的吲哚二酮并哌嗪衍生物(1-4)和9个已知的同系物(5-13)。化合物1-4的绝对构型通过NOESY实验和酸解产物的手性高效液相色谱分析确定。通过电子圆二色谱(ECD)计算，首次确定了前松果糖类5中C-8(羟基取代的季碳)的绝对构型。对所有化合物进行了卤虫致死活性、杀线虫活性、抗氧化活性和抗菌活性的测定。
Four new indolediketopiperazine derivatives (1–4), along with nine known congeners (5–13), were isolated and identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus obtained from the marine alga Sargassum thunbergii. The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds 1–4 were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in 5 of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp (Artemia salina) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency.