Forced swimming behavior is not related to the corticosterone levels achieved in the test: A study with four inbred rat strains
Forced swimming behavior is not related to the corticosterone levels achieved in the test: A study with four inbred rat strains
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DOI：
10.1016/0031-9384(95)02104-3
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发表时间：
1996-02-01
影响因子：
2.9
通讯作者：
Armario, A
中科院分区：
文献类型：
--
作者：
Marti, J;Armario, A
本实验研究了四个近交系成年雄性大鼠在孔板和强迫游泳实验中的行为及其与应激生理指标（血清皮质酮）的关系。菌株为：Fisher 344（FIS）、刘易斯（LEW）、自发性高血压（SHR）和Wistar-Kyoto（WKY）。在洞板中，SHR大鼠最活跃，WKY大鼠较不活跃，其他品系表现出中等水平的活动。在第一次暴露于强迫游泳期间，WKY比其他三种菌株更加被动，在第二次暴露期间也观察到了同样的情况。当皮质酮水平后，这第二次暴露于水进行了测定，LEW大鼠表现出较低的值比其他三个品系。因此，行为和应激诱导的皮质酮分泌之间不存在明显的关系。虽然单点测量压力的生理指标具有重要的局限性，但目前的数据并不支持动物在强迫游泳试验中的行为与对压力的情绪反应之间存在强烈的关系。因此，强迫游泳行为可能主要不是一种类似恐慌的反应，而是动物在不可避免的情况下采取被动策略的倾向的结果。尽管还需要更多的研究来坚定地建立这一假设，但WKY大鼠可能是一种有用的抑郁样行为模型。
The behavior of four inbred strains of rats in the holeboard and the forced swimming tests, and its relationship with a physiological index of stress (serum corticosterone) were studied in adult male rats. The strains were: Fisher 344 (FIS), Lewis (LEW), Spontaneously hypertensive (SHR), and Wistar-Kyoto (WKY). in the holeboard, SHR rats were the most active and WKY the less active, the other strains showing intermediate levels of activity. During the first exposure to forced swimming WKY were far more passive than the other three strains and the same was observed during the second exposure. When corticosterone levels after this second exposure to water was determined, LEW rats showed lower values than the other three strains. Therefore, no apparent relationship between behavior and stress-induced corticosterone secretion exists. Although a single point measurement of only on physiological index of stress has important limitations, the present data do not give support to a strong relationship between the behavior of the animals in the forced swimming test and emotional reactivity to stress. It is therefore possible that forced swimming behavior might not be mainly a panic-like reaction, but the result of the tendency of the animals to adopt passive strategies in inescapable situations. Although more studies are needed to firmly establish this assumption, WKY rats might be, at least potentially, a useful model of depressive-like behavior.