[Impact of gender on the dose-effect relationship of cisatracurium].
[Impact of gender on the dose-effect relationship of cisatracurium].
复制标题
性别对顺式阿曲库铵量效关系的影响[J].
DOI：
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发表时间：
2011
影响因子：
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通讯作者：
Q. Liang
中科院分区：
文献类型：
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作者：
Hong;Q. Liang
目的
评价性别差异对顺铂量效关系的影响。
方法
80例阿萨I或II级患者（40例男性和40例女性患者）接受择期腹部手术，接受咪达唑仑和芬太尼单次静脉注射。将男性和女性患者再分为4个相等组，分别接受20、30、40或50 µg/kg的顺铂静脉推注。使用神经肌肉传导监测仪测量神经肌肉阻滞，并根据拇收肌TOF T1的最大抑制百分比定义反应。根据剂量和效应数据的对数-概率单位转换，通过线性回归建立了顺铂的剂量-效应曲线。观察维库溴铵的起效时间。
结果
男性患者顺铂的ED_（95）为67.4±4.4 μg/kg，女性患者为48.7±1.0 μg/kg，差异有统计学意义（P<0.05）。4个剂量组的起效时间无显著性差异（P>0.05）。
结论
女性患者比男性患者对顺铂更敏感。
OBJECTIVE
To evaluate the impact of gender differences on the dose-effect relationship of cisatracurium.
METHODS
Eighty ASA class I or II patients (40 male and 40 female patients) undergoing elective abdominal surgeries received a single-dose intravenous injection of midazolam and fentanyl. The male and female patients were subdivided into 4 equal groups to receive a intravenous bolus of 20, 30, 40, or 50 µg/kg of cisatracurium. The neuromuscular block was measured using a neuromuscular transmission monitor, and the responses were defined in terms of the percentages of maximum suppression in T1 of TOF of the adductor pollicis muscle. According to log-probit transformation of the data of the dose and response, the dose-response curve of cisatracurium was established through linear regression. The onset time of vecuronium was also observed.
RESULTS
The ED95 value of cisatracurium in male patients was 67.4±4.4 µg/kg, significantly higher than that in female patients (48.7±1.0 µg/kg, P<0.05). No significant variation in the onset time was found in the 4 dose groups of either male or female patients (P>0.05).
CONCLUSION
Female patients are more sensitive to cisatracurium than male patients.