EFFECT OF LIPIDS ON EXPRESSION OF CELL TRANSFORMATION
EFFECT OF LIPIDS ON EXPRESSION OF CELL TRANSFORMATION
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DOI：
10.1016/s0014-4827(77)80041-4
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发表时间：
1977-01-01
影响因子：
3.7
通讯作者：
SHLOSS, J
中科院分区：
文献类型：
--
作者：
CORWIN, LM;HUMPHREY, LP;SHLOSS, J
The Kirsten sarcoma virus-transformed [mouse] cell line, K3T3, when grown in media containing delipidized fetal calf serum (AES), regained many of the properties of the untransformed parent cell, BALB/3T3. Such properties include morphology, adherence, saturation density and growth patterns. After growth for several passages in AES, return of K3T3 cells to unextracted fetal calf serum did not restore the transformed phenotype for many generations, although eventually it does return. Cholesterol and linoleic acid added in combination to the growth medium prevented the AES-induced change to the normal, untransformed phenotype. Vitamin E and linoleic acid, on the other hand, did not prevent such a change from taking place.
