Structure-property studies on carbohydrate-derived polymers for use as protein-resistant biomaterials
Structure-property studies on carbohydrate-derived polymers for use as protein-resistant biomaterials
复制标题
DOI：
10.1021/bm701013y
复制
发表时间：
2008-01-01
影响因子：
6.2
通讯作者：
Guan, Zhibin
中科院分区：
文献类型：
--
作者：
Metzke, Mark;Guan, Zhibin
在这里，我们描述了我们的碳水化合物衍生侧链醚类聚合物作为抗蛋白质生物材料的结构-性质研究。由简单碳水化合物衍生的单体通过缩聚反应合成了一系列侧链醚类聚合物，包括两种聚酯和两种聚酰胺。表面等离子体共振谱表明，具有不同立体化学重复单元的两种侧链过甲氧基化聚酯对非特异性蛋白质吸附有很好的抗性，表明聚合物立体化学对其抗蛋白质性能没有太大影响。在聚合物主链上引入酰胺键可以产生更显著的效果。虽然用酰胺键取代酯可以显著提高聚合物的降解稳定性，但由于引入了酰胺键，聚合物的蛋白质抗性大大降低。最后，我们的结果表明，自由羟基和酰胺基团虽然都是氢键供体，但似乎对聚合物的蛋白质抗性有不同的影响。由此可见，游离酰胺基团对蛋白质抗性的不利影响比游离羟基更大。这些结果表明，这一系列聚合物的抗蛋白质性能可以通过改变主链和侧链的官能团来定制。结合生物可降解性和功能化，这一系列碳水化合物衍生聚合物显示出作为生物医学应用的多功能生物材料的前景。
Here we describe structure-property studies on our carbohydrate-derived side-chain ether polymers as protein-resistant biomaterials. A series of side-chain ether polymers, including two polyesters and two polyamides, were prepared by condensation polymerization of monomers derived from simple carbohydrates. The two side-chain permethoxylated polyesters having different stereochemical repeating units demonstrate excellent resistance toward nonspecific protein adsorption as shown by surface plasmon resonance, indicating that the polymer stereochemistry does not have much effect on its protein-resistant properties. The introduction of amide bonds to polymer backbones leads to more pronounced effects. While the polymer degradation stability is significantly enhanced by replacing ester with amide linkages, the protein resistance for the polymer is greatly reduced by introduction of amide bonds. Finally, our results suggest that free hydroxyl and amide groups, while both are hydrogen-bond donors, seem to have different effects on protein resistant properties for polymers. It appears that free amide groups have more detrimental effect on protein resistance than free hydroxyl groups. These results show that the protein-resistant properties of this family of polymers can be tailored by modifying the backbone and side chain functionalities. In combination with the biodegradability and functionalizability, this family of carbohydrate-derived polymers shows promise as versatile biomaterials for biomedical applications.