A Review of Transcriptome Analysis in Pulmonary Vascular Diseases.
A Review of Transcriptome Analysis in Pulmonary Vascular Diseases.
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DOI：
10.1007/978-1-4939-7834-2_13
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Machado RF
中科院分区：
文献类型：
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作者：
Fraidenburg DR;Machado RF
转录组分析是研究肺血管疾病和肺动脉高压的有力工具。肺动脉高压是一种由几种独特病理组成的疾病过程，它们具有共同的临床定义，即肺循环内压力升高。因此，识别不同类型肺动脉高压之间的异同变得越来越重要。转录组分析无论是在动物模型的基础科学研究中，还是在各种不同类型肺动脉高压的临床研究中，都是一种非常宝贵的工具。这项工作已经确定了新的潜在候选基因，涉及疾病发生和进展的许多生化和分子途径，开发了基因特征来适当分类肺动脉高压类型和疾病的严重程度，并确定了导致疾病遗传形式的新基因突变。
Transcriptome analysis is a powerful tool in the study of pulmonary vascular disease and pulmonary hypertension. Pulmonary hypertension is a disease process that consists of several unique pathologies sharing a common clinical definition, that of elevated pressure within the pulmonary circulation. As such, it has become increasingly important to identify both similarities and differences among the different classes of pulmonary hypertension. Transcriptome analysis has been an invaluable tool both in the basic science research on animal models as well as clinical research among the various different groups of pulmonary hypertension. This work has identified new potential candidate genes, implicated numerous biochemical and molecular pathways in diseased onset and progression, developed gene signatures to appropriately classify types of pulmonary hypertension and severity of illness, and identified novel gene mutations leading to hereditary forms of the disease.