Overview of the actions of glucocorticoids on the immune response - A good model to characterize new pathways of immunosuppression for new treatment strategies
Overview of the actions of glucocorticoids on the immune response - A good model to characterize new pathways of immunosuppression for new treatment strategies
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DOI：
10.1196/annals.1321.009
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Franchimont, D
中科院分区：
文献类型：
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作者：
Franchimont, D
糖皮质激素用于治疗炎症和自身免疫性疾病以及预防移植物排斥已经超过50年。今天，他们的分子，细胞和药理学特性的知识允许更好地了解糖皮质激素介导的免疫抑制。糖皮质激素对免疫反应的各种肢体和组分具有动态和双向的活性谱，产生负面和正面影响。它们调节参与先天免疫应答引发的基因，而它们对适应性免疫应答的作用是抑制细胞（Th1）免疫和促进体液（Th2）免疫。有趣的是，糖皮质激素还可以通过影响树突状细胞的成熟和功能以及促进调节性高IL-10产生T细胞的发育来诱导对特异性抗原的耐受。因此，糖皮质激素的离体治疗用途可以代表自身免疫性疾病中细胞疗法的辅助治疗，避免糖皮质激素的长期有害副作用。因此，糖皮质激素对免疫系统作用的全景图为表征免疫抑制的重要生物学途径提供了一个有趣的模型。
Glucocorticoids have been used for over 50 years in the treatment of inflammatory and autoimmune diseases and in preventing graft rejection. Today, knowledge of their molecular, cellular, and pharmacological properties allows a better understanding of glucocorticoid-mediated immunosuppression. Glucocorticoids exert both negative and positive effects with a dynamic and bidirectional spectrum of activities on various limbs and components of the immune response. They modulate genes involved in the priming of the innate immune response, while their actions on the adaptive immune response are to suppress cellular (Th1) immunity and promote humoral (Th2) immunity. Interestingly, glucocorticoids can also induce tolerance to specific antigens by influencing dendritic cell maturation and function and promoting the development of regulatory high IL-10-producing T cells. The ex vivo therapeutic use of glucocorticoids could therefore represent an adjuvant treatment to cell therapy in autoimmune diseases, avoiding the long-term deleterious adverse effects of glucocorticoids. Thus, the panoramic view of glucocorticoid actions on the immune system provides an interesting model for characterizing important biological pathways of immunosuppression.