Atrial natriuretic peptide gene promoter polymorphism is associated with left ventricular hypertrophy in hypertension.
Atrial natriuretic peptide gene promoter polymorphism is associated with left ventricular hypertrophy in hypertension.
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DOI：
10.1042/cs20070109
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发表时间：
2008
期刊：
影响因子：
6
通讯作者：
H. Xue;Shu-xia Wang;Hu Wang;K. Sun;Xiao-dong Song;Weili Zhang;Chun-yan Fu;Yun-feng Han;R. Hui
中科院分区：
文献类型：
--
作者：
H. Xue;Shu-xia Wang;Hu Wang;K. Sun;Xiao-dong Song;Weili Zhang;Chun-yan Fu;Yun-feng Han;R. Hui
最近的研究表明，ANP（心房利钠肽）/NPRA（A 型利钠肽受体）系统可调节西方人群高血压中的心室重塑和心脏肥大。在本研究中，我们测试了 ANP 基因中的两个 SNP（单核苷酸多态性）（一个位于启动子中，一个位于外显子）与心脏肥大之间的关联。我们在 2118 名高血压患者（包括 945 名患有 LVH [左心室肥厚] 和 1173 名无 LVH）以及 816 名健康对照受试者中检验了这一假设。所有受试者均进行了 -A2843G 和 A188G 多态性基因分型。我们发现，与 AA 或 AG 基因型相比，-2843 位的 GG 基因型导致 LVH 的风险是 AA 或 AG 基因型的 2.2 倍，包括间隔壁厚度（GG 为 11.8+/-1.4 mm，而 AA 和 AG 分别为 10.9+/-1.4 和 10.7+/-1.3 mm；P0.05）。在高血压患者或对照组中，A188G 基因型与超声心动图变量之间未发现显着相关性（P>0.05）。总之，我们的研究结果表明，ANP 基因启动子中的 -A2843G 多态性可能是高血压患者发生 LVH 的遗传危险因素。
Recent studies suggest that the ANP (atrial natriuretic peptide)/NPRA (type A natriuretic peptide receptor) system modulates ventricular remodelling and cardiac hypertrophy in hypertension in Western populations. In the present study, we tested for any association between two SNPs (single nucleotide polymorphisms) in the ANP gene (one in the promoter and one exonic) with cardiac hypertrophy. We tested the hypothesis in 2118 hypertensive patients, including 945 with LVH [LV (left ventricular) hypertrophy] and 1173 without LVH, as well as 816 healthy control subjects. All subjects were genotyped for the -A2843G and A188G polymorphisms. We found that the GG genotype at position -2843 conferred a 2.2-fold risk for LVH compared with the AA or AG genotypes, including septal wall thickness (11.8+/-1.4 mm for GG compared with 10.9+/-1.4 and 10.7+/-1.3 mm for AA and AG respectively; P0.05). No significant association between the A188G genotype and echocardiographic variables was found in either hypertensive patients or controls (P>0.05). In conclusion, our findings indicate that the -A2843G polymorphism in the ANP gene promoter might be a genetic risk factor for the development of LVH in patients with hypertension.