Charge-selective claudin channels
Charge-selective claudin channels
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DOI：
10.1111/j.1749-6632.2012.06555.x
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Yu, Alan S. L.
中科院分区：
文献类型：
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作者：
Krug, Susanne M.;Guenzel, Dorothee;Yu, Alan S. L.
紧密连接蛋白是紧密连接屏障特性的主要决定因素。许多紧密蛋白已被证明通过收紧细胞旁通路发挥作用，但有一些是作为细胞旁通道发挥作用。虽然有些依赖于所分析细胞系的内源性紧密蛋白背景，但对于其他紧密蛋白，已显示出独特的电荷选择性。本文描述了阳离子选择性（claudin-2、claudin-10b、claudin-15）和阴离子选择性（claudin-10a、claudin-17）claudin以及具有争议通道特性的claudin（claudin-4、claudin-7、claudin-16）。它还描述了决定观察到的电荷选择性和孔隙特性的分子特性。在渗漏组织中，它们通过提供细胞旁离子选择性途径来广泛确定总体运输特性。在小肠中，claudin-2 和 claudin-15 在发育中的肠道中相互替换。在肾近端小管中，claudin-2、claudin-10 和 claudin-17 允许钠、氯和水的细胞旁重吸收。
Claudins are the main determinants of barrier properties of the tight junction. Many claudins have been shown to act by tightening the paracellular pathway, but several function as paracellular channels. While some depend on the endogenous claudin background of the analyzed cell line, for other claudins, a distinct charge-selectivity has been shown. This paper portrays cation-selective (claudin-2, claudin-10b, claudin-15) and anion-selective (claudin-10a, claudin-17) claudins and claudins with debatable channel properties (claudin-4, claudin-7, claudin-16). It also describes molecular properties determining the observed charge-selectivity and pore properties in general. In leaky tissues, they widely determine overall transport characteristics by providing paracellular ion-selective pathways. In small intestine, claudin-2 and claudin-15 replace each other in the developing gut. In kidney proximal tubules, claudin-2, claudin-10, and claudin-17 allow for paracellular reabsorption of sodium, chloride, and water.