Absorptive properties of synovium harvested from the carpal tunnel
Absorptive properties of synovium harvested from the carpal tunnel
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从腕管采集的滑膜的吸收特性
DOI：
10.1002/micr.10051
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发表时间：
2002
期刊：
影响因子：
2.1
通讯作者：
K. Grinspun
中科院分区：
文献类型：
--
作者：
V. Sud;M. Tucci;A. Freeland**;W. Smith;K. Grinspun
缺血诱导的再灌注损伤似乎在“特发性”腕管综合征（CTS）的病理生理学中起重要作用。这种发育顺序中的共同最终途径被认为是间质压力的间歇性增加，导致屈肌腱鞘的退行性变化和神经周围组织的纤维化变化。我们假设这同时导致滑膜物理性质的改变，导致其快速和持续的肿胀。对27例CTS患者的滑膜组织进行了前瞻性研究。CTS患者的体外滑膜吸收率在第一个小时内显著高于对照组（n = 7）。这种差异保持了5-6小时，尽管速度较慢。滑膜对液体的快速吸收和保留导致间质压力增加和神经压迫，导致致敏患者出现早期和持续的症状表现。© 2002 Wiley利斯公司显微外科22：316-319 2002
Ischemia‐induced reperfusion injury seems to play an important role in the pathophysiology of “idiopathic” carpal tunnel syndrome (CTS). The common final pathway in this developmental sequence is thought to be an intermittent increase in interstitial pressure, leading to degenerative changes in the flexor tenosynovium and fibrotic changes in the perineural tissue. We hypothesize that this concurrently leads to alteration in the physical properties of the synovium, leading to its rapid and persistent swelling. A prospective study was conducted on synovial tissue obtained from 27 CTS patients. The in vitro synovial absorption rate of CTS patients was significantly higher in the first hour compared to controls (n = 7). This difference was maintained up to 5–6 h, albeit at a slower rate. Rapid absorption and retention of fluid by the synovium led to increased interstitial pressure and nerve compression, resulting in early and persistent manifestation of symptoms in sensitized patients. © 2002 Wiley‐Liss, Inc. MICROSURGERY 22:316–319 2002