HIV-1 infection among intravenous drug users in Manhattan, New York City, from 1977 through 1987.
HIV-1 infection among intravenous drug users in Manhattan, New York City, from 1977 through 1987.
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DOI：
10.1001/jama.1989.03420070058030
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发表时间：
1989-02
期刊：
影响因子：
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通讯作者：
D. C. Jarlais;S. R. Friedman;D. Novick;J. L. Sotheran;Pauline A. Thomas;S. Yancovitz;D. Mildvan;J. M. Weber;M. Kreek;R. Maslansky;Sarah Bartelme;T. Spira;M. Marmor
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文献类型：
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作者：
D. C. Jarlais;S. R. Friedman;D. Novick;J. L. Sotheran;Pauline A. Thomas;S. Yancovitz;D. Mildvan;J. M. Weber;M. Kreek;R. Maslansky;Sarah Bartelme;T. Spira;M. Marmor
静脉注射吸毒者是获得性免疫缺陷综合征的第二大群体，在美国和欧洲，他们是异性恋和围产期传播的主要来源。了解人体免疫缺陷病毒在静脉注射吸毒者中传播的长期趋势对控制获得性免疫缺陷综合症的流行至关重要。获得性免疫缺陷综合征监测数据和药物治疗计划进入者的血清阳性率研究用于追踪曼哈顿区静脉注射吸毒者的血清阳性率趋势。该病毒在20世纪70年代中期进入这个吸毒群体，并在1979年至1983年迅速传播。从1984年到1987年，血清阳性率稳定在55%到60%之间，远低于乙型肝炎的血清阳性率。这一相对稳定的比率是由于新的感染，新的血清阴性者开始注射药物，血清阳性者离开注射药物，以及越来越有意识地减少风险。
Intravenous drug users are the second largest group to develop the acquired immunodeficiency syndrome, and they are the primary source for heterosexual and perinatal transmission in the United States and Europe. Understanding long-term trends in the spread of human immunodeficiency virus among intravenous drug users is critical to controlling the acquired immunodeficiency syndrome epidemic. Acquired immunodeficiency syndrome surveillance data and seroprevalence studies of drug treatment program entrants are used to trace seroprevalence trends among intravenous drug users in the borough of Manhattan. The virus entered this drug-using group during the mid-1970s and spread rapidly in 1979 through 1983. From 1984 through 1987, the seroprevalence rate stabilized between 55% and 60%--well below hepatitis B seroprevalence rates. This relatively constant rate is attributed to new infections, new seronegative persons beginning drug injection, seropositive persons leaving drug injection, and increasing conscious risk reduction.