Behavior and physiology of social stress and depression in female cynomolgus monkeys
Behavior and physiology of social stress and depression in female cynomolgus monkeys
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DOI：
10.1016/s0006-3223(96)00185-0
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发表时间：
1997-04-15
影响因子：
10.6
通讯作者：
Anton, RF
中科院分区：
文献类型：
--
作者：
Shively, CA;LaberLaird, K;Anton, RF
社会从属会给某些个体带来压力，并导致抑郁反应的假设，在社会饲养的雌性食蟹猴中进行了检验。社会地位受到操纵，使得一半以前处于从属地位的女性成为统治者，一半以前处于统治地位的女性变得从属。目前的下属皮质醇分泌过多，对负反馈不敏感，并且生殖功能受到抑制。与统治者相比，当前的下属受到更多的攻击，参与更少的附属关系，并且花更多的时间独处。此外，他们比占主导地位的人花更多的时间恐惧地审视社会环境，表现出更多的行为抑郁。目前有社会从属历史的下属更容易出现行为抑郁反应。该实验的结果表明，社会从属压力会导致下丘脑-垂体-肾上腺和卵巢功能障碍，并支持慢性、低强度的社会压力可能导致易感个体抑郁的假设。 (C) 1997 年生物精神病学协会。
The hypothesis that social subordination is stressful, and results in a depressive response in some individuals, was examined in socially housed female cynomolgus monkeys. Social status was manipulated such that half of the previously subordinate females became dominant and half of the previously dominant females became subordinate. Current subordinates hypersecreted cortisol, were insensitive to negative feedback, and had suppressed reproductive function. Current subordinates received more aggression, engaged in less affiliation, and spent more time alone than dominants. Furthermore, they spent more time fearfully scanning the social environment and displayed more behavioral depression than dominants. Current subordinates with a history of social subordination were preferentially susceptible to a behavioral depression response. The results of this experiment suggest that the stress of social subordination causes hypothalamic-pituitary-adrenal and ovarian dysfunction, and support the hypothesis that chronic, low-intensity social stress may result in depression in susceptible individuals. (C) 1997 Society of Biological Psychiatry.