Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds.
Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds.
复制标题
DOI：
10.1289/ehp275
复制
发表时间：
2017-07-26
影响因子：
10.4
通讯作者：
Budtz-Jørgensen E
中科院分区：
文献类型：
--
作者：
Grandjean P;Heilmann C;Weihe P;Nielsen F;Mogensen UB;Budtz-Jørgensen E
出生后暴露于全氟烷基化物物质（PFASs）与7岁时某些儿童疫苗特异性抗体的血清浓度降低有关。我们前瞻性地跟踪了法罗群岛的出生队列，以确定13岁时这些相关性。在516名13岁的受试者（合格队列成员的79%）中，测量PFAS和白喉和破伤风抗体的血清浓度，并与7岁时的既往检查数据进行比较。多元回归分析和结构方程模型，以确定出生后PFAS暴露和抗体浓度之间的关联。PFAS和抗体的血清浓度普遍下降，从7岁到13岁。然而，68名受试者曾到急诊室就诊，并可能接受了疫苗加强接种，共有202名儿童在13岁时的疫苗抗体浓度高于7岁时。因此，在排除这两个亚组后进行单独分析。白喉抗体浓度在13年和7年的PFAS浓度升高时下降;全氟癸酸（PFDA）在7年和全氟辛酸（PFOA）在13年的相关性具有统计学意义，这两种情况都表明暴露量每增加一倍就会降低。结构方程模型显示，对于5种PFAS，7年时PFAS暴露量增加一倍与13年时白喉抗体浓度损失10-30%相关。抗破伤风浓度几乎没有观察到相关性。这些结果与先前在当前暴露水平下PFAS免疫毒性的发现雅阁。https://doi.org/10.1289/EHP275
Postnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower serum concentrations of specific antibodies against certain childhood vaccines at 7 y. We prospectively followed a Faroese birth cohort to determine these associations at 13 y. In 516 subjects (79% of eligible cohort members) who were 13 years old, serum concentrations of PFASs and of antibodies against diphtheria and tetanus were measured and were compared with data from the previous examination at 7 y. Multiple regression analyses and structural equation models were applied to determine the association between postnatal PFAS exposures and antibody concentrations. Serum concentrations of PFASs and antibodies generally declined from 7 y to 13 y. However, 68 subjects had visited the emergency room and had likely received a vaccination booster, and a total of 202 children showed higher vaccine antibody concentrations at 13 y than at 7 y. Therefore, separate analyses were conducted after exclusion of these two subgroups. Diphtheria antibody concentrations decreased at elevated PFAS concentrations at 13 y and 7 y; the associations were statistically significant for perfluorodecanoate (PFDA) at 7 y and for perfluorooctanoate (PFOA) at 13 y, both suggesting a decrease by for each doubling of exposure. Structural equation models showed that a doubling in PFAS exposure at 7 y was associated with losses in diphtheria antibody concentrations at 13 y of 10–30% for the five PFASs. Few associations were observed for anti-tetanus concentrations. These results are in accord with previous findings of PFAS immunotoxicity at current exposure levels. https://doi.org/10.1289/EHP275