Serial Sampling of ST2 Predicts 90-Day Mortality Following Destabilized Heart Failure
Serial Sampling of ST2 Predicts 90-Day Mortality Following Destabilized Heart Failure
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DOI：
10.1016/j.cardfail.2008.06.415
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发表时间：
2008-11-01
影响因子：
6
通讯作者：
Fitzgerald, Robert L.
中科院分区：
文献类型：
--
作者：
Boisot, Saskia;Beede, Jennifer;Fitzgerald, Robert L.
背景：前瞻性地确定白细胞介素1受体家族成员连续抽样对预后的预测作用。ST2，用于预测退伍军人事务医疗中心入院的心力衰竭(HF)患者的90天死亡率。方法和结果：在加利福尼亚州圣地亚哥的退伍军人事务医疗系统对150名严重不稳定的HE患者住院进行了跟踪调查。测量包括ST2在内的多项心脏相关参数。B型利钠肽(BNP)、NT-ProBNP、血尿素氮(BUN)。从入院到出院的6个时间点采集血浆样本。生物标记物浓度与90天的存活期相关。使用单变量和多变量分析来确定预后变量。在出院前，ST2的百分比变化对90天的死亡率有很强的预测作用：那些在研究期间ST2值下降15.5%或更多的患者有7%的死亡机会。而ST2水平在这段时间间隔内未能下降15.5%的患者死亡的几率为33%。结论：在急性心力衰竭治疗期间，ST2浓度的百分比变化可以预测90天的死亡率，WITS独立于BNP或NT-proBNP水平。ST2可为临床医生提供额外的1001，用于指导急性不稳定肝性脑病患者的治疗(心脏衰竭杂志2008：14：732-738)
Background: To prospectively determine the prognostic utility of serial sampling of the interleukin-1 receptor family member. ST2, for predicting 90-day mortality in patients with heart failure (HF) admitted to a Veteran Affairs Medical Center.Methods and Results: A total 150 patients hospitalized with acutely destabilized HE were followed at the Veteran Affairs Healthcare System in San Diego, CA. Multiple cardiac-related parameters were measured including ST2. B-type natriuretic peptide (BNP), NT-proBNP, and blood urea nitrogen (BUN). Plasma samples were collected ill 6 time points between admission and discharge. Biomarker concentrations were correlated to survival at 90 days. Uni- and multivariate analyses Were used to identify prognostic variables. Front admission to discharge, percent change in ST2 was strongly predictive of 90-day mortality: those patients whose ST2 values decreased by 15.5% or more during the study period had a 7% chance of death. whereas patients whose ST2 levels failed to decrease by 15.5% ill this time interval had a 33% chance of dying.Conclusions: Percent change in ST2 concentrations during acute HF treatment is predictive of 90-day mortality and wits independent of BNP or NT-proBNP levels. ST2 may provide clinicians with an additional 1001 for guiding treatment in patients With acute destabilized HE (J Cardiac Fail 2008:14:732-738)