Targeting eosinophils in asthma.
Targeting eosinophils in asthma.
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DOI：
10.2174/156652408785748013
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发表时间：
2008-09
影响因子：
2.5
通讯作者：
Kumar RK
中科院分区：
文献类型：
--
作者：
Foster PS;Rosenberg HF;Asquith KL;Kumar RK
嗜酸性粒细胞的募集长期以来被认为是哮喘炎症反应的一个标志。然而，这类细胞在宿主防御中的功能仍知之甚少。嗜酸性粒细胞在炎症反应中起重要作用，并且在免疫反应的传入支中具有关键的调节作用。最近，已证实嗜酸性粒细胞参与宿主对呼吸道病毒的防御。嗜酸性粒细胞对哮喘病理生理学的具体作用仍存在争议。然而，证据的平衡表明它们在该疾病中具有重要作用，这意味着它们可能是合适的治疗靶点。为此，一种具有相当潜在研究价值的新干预措施是使用一种针对白细胞介素 - 3、白细胞介素 - 5和粒细胞 - 巨噬细胞集落刺激因子受体的β共同链的抗体。然而，消除嗜酸性粒细胞可能不是一种无风险的治疗策略，因为可能会增加呼吸道病毒感染的可能性。这可能会诱发哮喘急性加重，这一结果将具有重大的临床意义。
Recruitment of eosinophils has long been recognized as a hallmark of the inflammatory response in asthma. However, the functions of this population of cells in host defense remain poorly understood. Eosinophils play an important part in the inflammatory response and have key regulatory roles in the afferent arm of the immune response. More recently, eosinophils have been demonstrated to participate in host defense against respiratory viruses. The specific contributions of eosinophils to the pathophysiology of asthma remains controversial. However, the balance of evidence indicates that they have a significant role in the disease, suggesting that they may be appropriate targets for therapy. Towards this end, a novel intervention of considerable potential interest is the use of an antibody directed against the β-common chain of the receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. However, eliminating eosinophils may not be a risk-free therapeutic strategy, as there is potentially an increased likelihood of respiratory viral infections. This may predispose to the development of acute exacerbations of asthma, an outcome that would have significant clinical implications.