Resolving differences between animal models for expedited orthodontic tooth movement
Resolving differences between animal models for expedited orthodontic tooth movement
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DOI：
10.1111/ocr.12175
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发表时间：
2017-06-01
影响因子：
3.1
通讯作者：
Huja, S. S.
中科院分区：
文献类型：
--
作者：
Ibrahim, A. Y.;Gudhimella, S.;Huja, S. S.
结构化AbstractObjectives突出的差异，在常用的动物模型的正畸牙齿移动（OTM）.MethodsNarrative review.ResultsA关键审查的动物模型的文献已经变得越来越重要，在过去的十年中，方法，以增加牙齿移动的速度一直在强烈寻求。我们提供了一个审查，重点是啮齿动物和犬模型加快OTM和描述的挑战外推的结果，以临床实践的药物。我们回顾并对比了两种（啮齿动物，犬）最常用的OTM动物模型。然后，我们描述动物模型来研究骨适应，重塑和建模，这是描述和量化OTM.ConclusionsUnderstanding动物模型和它们的适应生物学之间的差异，因为它涉及到OTM的关键事件，使有效的结论。啮齿动物模型可用于理解牙齿移动的初始阶段。与狗模型不同，啮齿动物模型不适合理解身体牙齿移动的长期适应。从啮齿动物模型数据推断人类的牙齿移动速率更具挑战性。
Structured AbstractObjectiveTo highlight differences in commonly used animal models of orthodontic tooth movement (OTM).MethodsNarrative review.ResultsA critical review of the literature on animal models has become increasingly important in the last decade as methods to increase the rate of tooth movement have been intensely sought. We provide a review focusing on the rodent and canine models for expedited OTM and describe the challenges in extrapolation of the results to the clinical practice of orthodontics. We review and contrast the two (rodent, canine) most commonly used animal models for OTM. We then describe animal models to study bone adaptation, remodelling and modelling, which are keys events in describing and quantifying OTM.ConclusionsUnderstanding the differences between animal models and their adaptation biology as it relates to OTM is key to make valid conclusions. The rodent model can be used to understand the initial phases of tooth movement. Unlike the dog model, the rodent model does not lend itself to understand prolonged adaptation in response to bodily tooth movement. Extrapolation of rate of tooth movement to humans is more challenging from rodent model data.