The impact of mathematical modeling on the understanding of diabetes and related complications.
The impact of mathematical modeling on the understanding of diabetes and related complications.
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DOI：
10.1038/psp.2013.30
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发表时间：
2013-07-10
影响因子：
3.5
通讯作者：
Chelliah, V
中科院分区：
文献类型：
--
作者：
Ajmera, I;Swat, M;Laibe, C;Le Novere, N;Chelliah, V
糖尿病是一种由持续高血糖引起的慢性、复杂的多因素疾病，其潜在的发病机制尚不完全清楚。葡萄糖稳态、糖尿病病情及其相关并发症的数学模型正在迅速发展，并为相关的潜在机制提供了新的见解。在这里，我们讨论了过去五十年来对糖尿病建模领域的贡献，突出了需要更集中研究的领域。
Diabetes is a chronic and complex multifactorial disease caused by persistent hyperglycemia and for which underlying pathogenesis is still not completely understood. The mathematical modeling of glucose homeostasis, diabetic condition, and its associated complications is rapidly growing and provides new insights into the underlying mechanisms involved. Here, we discuss contributions to the diabetes modeling field over the past five decades, highlighting the areas where more focused research is required.