Evaluating memory testing to distinguish dementia severity among White, Black, and Spanish-speaking individuals in the Uniform Data Set (UDS).
Evaluating memory testing to distinguish dementia severity among White, Black, and Spanish-speaking individuals in the Uniform Data Set (UDS).
复制标题
评估记忆测试，以区分统一数据集 (UDS) 中白人、黑人和西班牙语个体的痴呆症严重程度。
DOI：
10.1002/alz.13002
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Sano,Mary
中科院分区：
文献类型：
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作者：
Loizos,Maria;Zhu,CarolynW;Akrivos,Jimmy;Sewell,Margaret;Li,Clara;Neugroschl,Judith;Melnick,Jonah;Ljekocevic,Martin;Martin,Jane;Grossman,Hillel;Aloysi,Amy;Schimming,Corbett;Sano,Mary
很少有研究比较了在不同的研究队列中单独或联合使用多种类型的记忆测试来区分痴呆症严重程度的有效性，其中包括黑人个体和说西班牙语的人。方法采用统一数据集(UDS)和特定部位补充数据、Logistic回归模型和受试者操作特征曲线下面积，比较了段落回忆和词汇表在区分临床痴呆评定量表(CDR)水平上的差异。结果显示，在区分临床痴呆评定量表(CDR)水平上，所有组都有很高的可识别性，两种测试在区分CDR水平上没有差异。联合测试提高了整个群体的辨别能力，但对黑人个人或说西班牙语的人却没有。讨论：研究结果表明，使用多项记忆测试可能不会改善不同队列中认知障碍水平的差异。增加测试的负担可能是最大限度地将代表不足的群体纳入研究的障碍。
INTRODUCTIONLittle work has compared the effectiveness of using multiple types of memory tests alone or in combination to distinguish dementia severity in diverse research cohorts including Black individuals and Spanish speakers. Here we evaluate word list and paragraph recall tests to distinguish cognitively normal, mild cognitively impaired, and those with Alzheimer's disease in diverse cohorts.METHODSUsing Uniform Data Set (UDS) and site‐specific supplemental data, logistic regression models and receiver operating characteristic–area under the curve were used to compare paragraph recall versus word list in differentiating among Clinical Dementia Rating (CDR) scale level.RESULTSResults reveal high discriminability for all groups and no difference between either test in distinguishing between CDR levels. Combining tests improved discriminability for the whole group but did not for Black individuals or Spanish speakers.DISCUSSIONOur findings indicate that using multiple memory tests may not improve differentiation between cognitive impairment levels for diverse cohorts. The burden of added testing may be a barrier for maximizing inclusion of under‐represented groups in research.