The effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-β1) and platelet-derived growth factor (PDGF)-A at the wound site in rats
The effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-β1) and platelet-derived growth factor (PDGF)-A at the wound site in rats
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DOI：
10.1080/08977190802025339
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发表时间：
2008-01-01
期刊：
影响因子：
1.8
通讯作者：
Pamir, M. Necmettin
中科院分区：
文献类型：
--
作者：
Konya, Deniz;Gercek, Arzu;Pamir, M. Necmettin
在细胞水平，脊髓损伤（SCI）引起炎症反应，在脊髓内产生大量的继发性损伤，但也可能有助于其修复。本研究的目的是研究SCI相关炎症反应对大鼠皮肤伤口愈合的影响，以及对伤口部位转化生长因子-β 1（TGF-β 1）和血小板衍生生长因子（PDGF）-A表达的影响。在第14天的分析中，创伤组（I）的平均TGF-β（1）评分显著低于对照组（C）（分别为2.60 +/- 0.90 vs. 3.64 +/- 0.37; p < 0.05）。I组中PDGF-A表达的平均评分与C组中的相应值相似（分别为2.42 +/- 0.74 vs. 2.94 +/- 0.72）。与C组相比，I组的表皮和真皮再生平均评分显著降低，但肉芽组织厚度平均评分较高，血管生成评分相似。真皮层含有胶原纤维的弥漫性沉积，其不像在对照大鼠皮肤中那样组织化，并且表皮内和表皮下血管充血是明显的。根据研究中评估的参数结果，大鼠实验性SCI导致伤口愈合延迟和背部伤口组织标本中TGF-β（1）的低强度。
At the cellular level, spinal cord injury (SCI) provokes an inflammatory response that generates substantial secondary damage within the cord, but also may contribute to its repair. The aim of this study was to investigate the effects of inflammatory response associated with SCI in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta(1)) and platelet-derived growth factor (PDGF)-A at the wound site in rats. At the 14th day analysis, the mean TGF-beta(1) score in trauma group (I) was significantly lower than that in control group (C) (2.60 +/- 0.90 vs. 3.64 +/- 0.37, respectively; p < 0.05). The mean score for PDGF-A expression in group I was similar to the corresponding value in group C (2.42 +/- 0.74 vs. 2.94 +/- 0.72, respectively). Compared to group C, group I had significantly lower mean scores for epidermal and dermal regeneration, but higher mean scores for granulation tissue thickness and similar scores for angiogenesis. The dermal layer contains diffuse deposition of collagen fibers that are not organised as in control rat skin, and intraepidermal and subepidermal vasocongestion is distinct. Based on the results on the parameters evaluated in the study, experimental SCI in rats results in delay in wound healing and low intensity of TGF-beta(1) in the dorsal wound-tissue specimens.