Application for hyperthermia treatment of an experimental tumor using a gyrotron (107, 203 GHz)
Application for hyperthermia treatment of an experimental tumor using a gyrotron (107, 203 GHz)
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DOI：
10.1109/icimw.2009.5324792
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发表时间：
2009-11
期刊：
影响因子：
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通讯作者：
N. Miyoshi;Y. Fukunaga;I. Ogawa;T. Idehara
中科院分区：
文献类型：
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作者：
N. Miyoshi;Y. Fukunaga;I. Ogawa;T. Idehara
我们使用回旋加速器对实验性移植前列腺癌模型小鼠进行了太赫兹波照射。分别用107 GHz和203 GHz(22.56W/cm2×20min=27,180J/cm2)照射12周龄小鼠BALB-c-nu/nu株肿瘤模型，分别在43℃升温10min和43℃恒温10min。治疗前后每天测量肿瘤模型大小(Axbxcx、π/6 mm~3)。结果发现，在培养的人腺瘤细胞(PC-3)移植瘤的情况下，203和107 GHz两个波数的照射对肿瘤的辐射抗肿瘤作用比对照组降低了1000多倍。
We have applied the terahertz wave irradiation to an experimental transplanted prostate cancer model mouse using the gyrotron. We irradiated the 107 or 203 GHz wave (22.56W/cm2 × 20 min = 27,180 J/cm2), resepectively, against the tumor model BALB-c-nu/nu strain, mail, 12 week old mouse at 43 degree C, which to rising time for 10 min and to keeping the temperature at 43 degree C for 10 min, respectively. The cancer model sizes (axbxcxπ/6 mm3) were measured every day before and after the treatment. In the results, the irradiation anti-tumor effect by the both wave numbers of 203 and 107 GHz for the cancer was found in the case of the transplanted tumor with a cultivated human adenoma cell (PC-3) to decrease more than thousand times comparing the control.