EFFECTS ON NEONATE OF PREDNISONE AND AZATHIOPRINE ADMINISTERED TO MOTHER DURING PREGNANCY
EFFECTS ON NEONATE OF PREDNISONE AND AZATHIOPRINE ADMINISTERED TO MOTHER DURING PREGNANCY
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DOI：
10.1016/s0022-3476(74)80109-5
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发表时间：
1974-01-01
影响因子：
5.1
通讯作者：
PICKERING, RJ
中科院分区：
文献类型：
--
作者：
COTE, CJ;MEUWISSEN, HJ;PICKERING, RJ
We have reported a male infant whose mother was treated throughout pregnancy with large doses of azathioprine and prednisone for chronic renal disease. At birth, the child manifested lymphopenia, diminished thymic radiographic shadow, and low serum concentrations of immunoglobulins M and G. Cytomegalovirus (CMV) was cultured from maternal urine and from the infant's urine at 10 weeks of age. The patient developed satisfactorily in the postnatal period and his immune status returned to normal. More than one year after birth the child appears to have developed adequately and, with the exception of low serum IgA concentration and persistent CMV infection, appears to have intact immunologic responses. Our observations in this patient and information derived from a literature review emphasize the need for short-and long-term clinical and laboratory evaluation of infants born to mothers who have been receiving immunosuppressive and potentially carcinogenic drugs during pregnancy.
