Symmetric spike timing-dependent plasticity at CA3-CA3 synapses optimizes storage and recall in autoassociative networks.
Symmetric spike timing-dependent plasticity at CA3-CA3 synapses optimizes storage and recall in autoassociative networks.
复制标题
CA 3-CA 3突触的对称尖峰时间依赖性可塑性优化了自联想网络中的存储和回忆。
DOI：
10.1038/ncomms11552
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发表时间：
2016-05-13
影响因子：
16.6
通讯作者：
Jonas P
中科院分区：
文献类型：
--
作者：
Mishra RK;Kim S;Guzman SJ;Jonas P
CA3-CA3 周期性兴奋性突触被认为在记忆存储和模式完成中发挥关键作用。这些突触的可塑性是否与其提出的网络功能一致仍不清楚。在这里，我们检查 CA3-CA3 突触的尖峰时间依赖性可塑性 (STDP) 的特性。兴奋性突触后电位 (EPSP) 和动作电位 (AP) 的低频配对可诱导长时程增强 (LTP)，与时间顺序无关。 STDP 曲线是对称且宽的（半宽~150 ms）。与这些 STDP 感应特性一致，AP-EPSP 序列导致脊柱 [Ca2+] 瞬变的超线性求和。此外，AP 后的后去极化 (ADP) 有效传播到 CA3 锥体神经元的树突中，EPSP 与树突 ADP 相加。在自关联网络模型中，对称 STDP 规则的存储和调用比非对称 STDP 规则更稳健。因此，专门的 STDP 归纳规则可以实现海马 CA3 网络中信息的可靠存储和调用。 STDP 取决于突触前和突触后活动的时间。在这里，作者描述了 CA3-CA3 突触的对称 STDP 诱导规则，该规则在广泛的配对间隔内诱导 LTP。建模表明该 STDP 规则可以增强 CA3 单元网络中的存储容量和模式完成。
CA3–CA3 recurrent excitatory synapses are thought to play a key role in memory storage and pattern completion. Whether the plasticity properties of these synapses are consistent with their proposed network functions remains unclear. Here, we examine the properties of spike timing-dependent plasticity (STDP) at CA3–CA3 synapses. Low-frequency pairing of excitatory postsynaptic potentials (EPSPs) and action potentials (APs) induces long-term potentiation (LTP), independent of temporal order. The STDP curve is symmetric and broad (half-width ∼150 ms). Consistent with these STDP induction properties, AP–EPSP sequences lead to supralinear summation of spine [Ca2+] transients. Furthermore, afterdepolarizations (ADPs) following APs efficiently propagate into dendrites of CA3 pyramidal neurons, and EPSPs summate with dendritic ADPs. In autoassociative network models, storage and recall are more robust with symmetric than with asymmetric STDP rules. Thus, a specialized STDP induction rule allows reliable storage and recall of information in the hippocampal CA3 network. STDP is dependent on the timing of pre- and post-synaptic activity. Here, the authors describe a symmetric STDP induction rule at CA3-CA3 synapses, which induces LTP over a broad range of paring intervals. Modelling suggests that this STDP rule may enhance storage capacity and pattern completion in the CA3 cell network.