Dissociation of pavlovian and instrumental incentive learning under dopamine antagonists
Dissociation of pavlovian and instrumental incentive learning under dopamine antagonists
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DOI：
10.1037/0735-7044.114.3.468
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发表时间：
2000-06-01
影响因子：
1.9
通讯作者：
Mirenowicz, J
中科院分区：
文献类型：
--
作者：
Dickinson, A;Smith, J;Mirenowicz, J
多巴胺拮抗剂匹莫齐特和氟哌噻吨的给药。当条件刺激（CS）与非偶然食物奖励配对时，对大鼠的巴甫洛夫工具转移减少。在巴甫洛夫条件反射和/或测试期间给予拮抗剂废除了CS对仪器性能的增强。两个拮抗剂对工具性激励学习的影响进行了研究。训练后，大鼠对不同的食物奖励进行2种反应，在再暴露期间，它们在拮抗剂下消耗1种食物，在载体下消耗另一种食物。当随后在灭绝中测试工具性反应时，大鼠是否再次暴露于拮抗剂下的训练奖励并不影响其表现。这些结果表明，巴甫洛夫和工具激励学习是不介导的一个共同的过程。
The administration of the dopamine antagonists, pimozide and ol-flupenthixol. to rats reduced Pavlovian-instrumental transfer when a conditioned stimulus (CS) that had been paired with a noncontingent food reward was tested on instrumental performance. The administration of the antagonists during Pavlovian conditioning and/or testing abolished the enhancement of instrumental performance by the CS. The effect of both antagonists on instrumental incentive learning was then examined. After training in which the rats performed 2 responses for different food rewards, they consumed 1 type food under the antagonists and the other type under vehicle during reexposure. When instrumental responding was subsequently tested in extinction, performance was unaffected by whether the rats had been reexposed to the training reward under the antagonists. These results suggest that Pavlovian and instrumental incentive learning are not mediated by a common process.