Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome: evaluation of drug distribution in a rat glioma model
Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome: evaluation of drug distribution in a rat glioma model
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DOI：
10.1080/02656730410001703186
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发表时间：
2004-09-01
影响因子：
3.1
通讯作者：
Tanaka, R
中科院分区：
文献类型：
--
作者：
Aoki, H;Kakinuma, K;Tanaka, R
提出了一种利用热敏脂质体靶向化疗治疗恶性胶质瘤的方法。使用大脑加热系统，当肿瘤核心被加热到零下43度时，肿瘤浸润区暴露在轻度高温下（40-43度）。设计了热敏脂质体，在40度时释放其内容物，同时靶向肿瘤核心和肿瘤浸润区。本研究在肿瘤药物摄取和肿瘤生长延缓研究中探讨了大鼠胶质瘤模型的抗肿瘤作用。大鼠C6胶质瘤治疗后，在加热至bb0 - 40℃的区域，ADR积累增加。然而，加热到40-42度和bb0 - 43度的区域之间没有显著差异。此外，我们还发现轻度高热区域的ADR浓度在脂质体ADR治疗后明显高于自由ADR治疗。与接受其他治疗的动物相比，接受新的联合治疗的动物的总生存时间明显更长。因此，热敏脂质体在轻度高温下释放其内容物，这种联合疗法对恶性脑肿瘤有更大的治疗效果。这种方法是治疗恶性胶质瘤的一种很有前途的方法。
A method was developed of targeting chemotherapy using thermosensitive liposomes to treat malignant gliomas. Using the brain heating system, when the tumour core is heated to >43degreesC, the tumour infiltrating zone is exposed to mild hyperthermia (40-43degreesC). Thermosensitive liposomes were designed to release their contents at 40degreesC to target both the tumour core and tumour infiltrating zone. The present study investigated the anti-tumour effect on rat glioma models in tumour drug uptake and tumour growth delay studies. Elevated accumulation of ADR in the rat C6 glioma after treatment was obtained in the area heated to >40degreesC. However, there was no significant difference between the areas heated to 40-42degreesC and >43degreesC. Furthermore, it was found that ADR concentrations in the mildly hyperthermic areas were significantly higher following treatment with liposomal ADR than with free ADR. The animals treated with the new combination therapy had significantly longer overall survival time in comparison to those receiving other treatments. Thus, thermosensitive liposomes release their contents in response to mild hyperthermia and this combination therapy has a greater therapeutic efficacy for malignant brain tumours. This method is a promising approach for the treatment of malignant glioma patients.