Soluble CD146 and B-type natriuretic peptide dissect overhydration into functional components of prognostic relevance in haemodialysis patients
Soluble CD146 and B-type natriuretic peptide dissect overhydration into functional components of prognostic relevance in haemodialysis patients
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DOI：
10.1093/ndt/gfy113
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发表时间：
2018-11-01
影响因子：
6.1
通讯作者：
Cippa, Pietro E.
中科院分区：
文献类型：
--
作者：
Arrigo, Mattia;Von Moos, Seraina;Cippa, Pietro E.
背景资料。准确的容量状态评估和水合过度的心脏和非心脏成分的区分是优化血液透析(HD)管理的基础。这项研究通过结合生物阻抗测量、心血管生物标志物和超声心动图，旨在将OH分解为其主要功能成分，并前瞻性地测试OH的心脏和非心脏成分与死亡率的关系。在第一部分中，我们在30名HD患者队列中验证了可溶性CD146(SCD146)作为全身充血的非心脏生物标志物。在第二部分中，我们对144名HD患者进行了一项为期一年的前瞻性随访研究。结果。透析后短间期和长间期sCD146逐渐升高(+53 ng/m L，P=0.006和+91 ng/m L，P
Background. Accurate volume status evaluation and differentiation of cardiac and non-cardiac components of overhydration (OH) are fundaments of optimal haemodialysis (HD) management.Methods. This study, by combining bioimpedance measurements, cardiovascular biomarkers and echocardiography, aimed at dissecting OH into its major functional components, and prospectively tested the association between cardiac and noncardiac components of OH with mortality. In the first part, we validated soluble CD146 (sCD146) as a non-cardiac biomarker of systemic congestion in a cohort of 30 HD patients. In the second part, we performed a prospective 1-year follow-up study in an independent cohort of 144 HD patients. Results. sCD146 incrementally increased after the short and long intervals after HD (+53 ng/mL, P = 0.006 and +91 ng/mL, P