Engineering analysis of diamond-like carbon coated polymeric materials for biomedical applications
Engineering analysis of diamond-like carbon coated polymeric materials for biomedical applications
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DOI：
10.1046/j.1525-1594.2000.06576.x
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发表时间：
2000-08-01
影响因子：
2.4
通讯作者：
Fukui, Y
中科院分区：
文献类型：
--
作者：
Alanazi, A;Nojiri, C;Fukui, Y
类金刚石(DLC)薄膜具有与金刚石相似的性能：硬度、导热性、耐化学腐蚀性、耐磨性、良好的生物相容性和均匀的平整表面，近年来受到了人们的广泛关注。此外，在室温下，DLC薄膜可以很容易地沉积在多种衬底上，用于大面积涂层。DLC薄膜是为血液接触设备(如旋转式血泵)中的生物医学材料而开发的，并对这些应用表现出良好的生物相容性。在本研究中，我们使用原子力显微镜(AFM)和Hi-vision相机、扫描电子显微镜(SEM)对表面粗糙度进行了研究。利用射频辉光放电等离子体在几种聚碳酸酯衬底上常温低压(53Pa)分解烃类气体制备了类金刚石薄膜。为了评价沉积速率与血小板粘附性之间的关系，我们在相同的甲烷压力下沉积了几次DLC膜，并考察了膜的厚度，此外，在聚合物衬底上沉积DLC膜的速率与在硅衬底上沉积的DLC膜的沉积速率相似。不同沉积速率(16~40 nm)的DLC薄膜对衬底表面粗糙度影响不大。研究了DLC膜的表面能和接触角。并对DLC膜的化学键进行了评价。讨论了多种方法和测量方法对表面性质的评价，以及血小板附着力与膜厚之间的关系。最后，提出的DLC膜似乎是生物医学应用和价值研究的前提。
Diamond-like carbon (DLC) films have received much attention recently owing to their properties, which are similar to diamond: hardness, thermal conductivity, corrosion resistance against chemicals, abrasion resistance, good biocompatibility, and uniform flat surface. Furthermore, DLC films can be deposited easily on many substrates for wide area coat at room temperature. DLC films were developed for applications as biomedical materials in blood contacting-devices (e.g., rotary blood pump) and showed good biocompatibility for these applications. In this study, we investigated the surface roughness by Atomic Force Microscopy (AFM) and Hi-vision camera, SEM for surface imaging. The DLC films were produced by radio frequency glow discharge plasma decomposed of hydrocarbon gas at room temperature and low pressure (53 Pa) on several kinds of polycarbonate substrates. For the evaluation of the relation between deposition rate and platelet adhesion that we investigated in a previous study, DLC films were deposited at the same methane pressure for several deposition times, and film thickness was investigated, in addition, the deposition rate of DLC films on polymeric substrates is similar to the deposition rate of those deposited on Si substrates. There were no significant differences in substrates' surface roughness that were coated by DLC films in different deposition rates (16-40 nm). The surface energy and the contact angle of the DLC films were investigated. The chemical bond of DLC films also was evaluated. The evaluation of surface properties by many methods and measurements and the relationship between the platelet adhesion and film thickness is discussed. Finally, the presented DLC films appear to be premising candidates for biomedical applications and merit investigation.