The Ubiquitin-Proteasome System of Saccharomyces cerevisiae
The Ubiquitin-Proteasome System of Saccharomyces cerevisiae
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DOI：
10.1534/genetics.112.140467
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发表时间：
2012-10-01
期刊：
影响因子：
3.3
通讯作者：
Kaiser, Peter
中科院分区：
文献类型：
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作者：
Finley, Daniel;Ulrich, Helle D.;Kaiser, Peter
蛋白质修饰为细胞提供了对蛋白质功能的精确的时间和空间控制。泛素是最重要的修饰剂之一，它既可以靶向数百种蛋白质，使其被蛋白酶体快速降解，又可以作为调节共价结合蛋白质功能的动态信号传导剂。泛素化的不同影响反映了目标蛋白上结构不同的泛素链的组装。由此产生的泛素代码由广泛的泛素受体家族进行解释。在这里，我们回顾了该调节网络的组成部分及其在整个细胞中的影响。
Protein modifications provide cells with exquisite temporal and spatial control of protein function. Ubiquitin is among the most important modifiers, serving both to target hundreds of proteins for rapid degradation by the proteasome, and as a dynamic signaling agent that regulates the function of covalently bound proteins. The diverse effects of ubiquitylation reflect the assembly of structurally distinct ubiquitin chains on target proteins. The resulting ubiquitin code is interpreted by an extensive family of ubiquitin receptors. Here we review the components of this regulatory network and its effects throughout the cell.