FAMILIAL RESEMBLANCE IN THE BLOOD-PRESSURE RESPONSE TO SODIUM RESTRICTION
FAMILIAL RESEMBLANCE IN THE BLOOD-PRESSURE RESPONSE TO SODIUM RESTRICTION
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DOI：
10.1093/oxfordjournals.aje.a114719
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发表时间：
1987-11-01
影响因子：
5
通讯作者：
DAUGHERTY, SA
中科院分区：
文献类型：
--
作者：
MILLER, JZ;WEINBERGER, MH;DAUGHERTY, SA
研究了血压正常者对限钠的血压反应的家族相似性。44个同卵双胞胎儿童的家庭参加了钠限制（≤ 0.001）。75 meq/天）方案持续12周的时间。受试者是印第安纳州[美国]中部的居民，研究进行了三年。在随意钠摄入与限制钠摄入的条件下，父母-子女和兄弟姐妹-兄弟姐妹的实际血压比值没有差异。在收缩压（p < 0.001）、舒张压（p < 0.05）和平均动脉压（p <0.05）方面，限钠后血压变化的母子相似性显著。同胞-同胞和双胞胎-双胞胎的相似性对于所有三种血压的变化也非常显著。父-子遗传相似性为边缘（p < 0.10）。据作者所知，这项研究首次证明了血压正常者限钠后血压变化的显著家族相似性。
Familial resemblance in the blood pressure response to sodium restriction in normotensive persons was investigated. Forty-four families of identical twin children participated in a sodium restriction (.ltoreq. 75 meq/day) protocol for a period of 12 weeks. Subjects were residents of central Indiana [USA], and the study was conducted over a three-year period. Parent-offspring and sibling-sibling resemblances for actual blood pressure were not different under conditions of ad lib sodium intake versus sodium restriction. Mother-offspring resemblance in blood pressure change with sodium restriction was significant for systolic (p < 0.001), diastolic (p < 0.05), and mean arterial (p < 0.05) pressures. Sibling-sibling and twin-twin resemblances were also highly significant for the change in all three blood pressures. Father-offspring resemblances were marginal (p < 0.10). This study is, to the author''s knowledge, the first to demonstrate significant familial resemblances in blood pressure change with sodium restriction in normotensive persons.