Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma
Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma
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DOI：
10.1210/jc.81.11.4042
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发表时间：
1996-11-01
影响因子：
5.8
通讯作者：
Nagura, H
中科院分区：
文献类型：
--
作者：
Sasano, H;Frost, AR;Nagura, H
雌激素的原位生成在人乳腺癌芳香酶的发育和生物学行为中起着重要作用，17β-羟基类固醇脱氢酶1(17β-HSD 1)是参与雌激素原位生成的两种主要酶。应用免疫组织化学方法检测41例浸润性乳腺癌(小叶癌19例，导管癌22例)中芳香化酶和17β-HSD-1的表达。然后，我们研究了这些酶的表达、雌激素(ER)和孕酮(PR)受体状态、癌细胞Ki67标记指数、年龄和患者临床分期之间的相关性。41例癌旁间质细胞中32例(78%)有明显的芳香酶免疫反应，23例(56%)癌细胞中有17例β-HSD-1免疫反应阳性。17β-HSD1在浸润性小叶癌中的表达与芳香化酶的表达显著相关(P=0.0119)，而在浸润性导管癌中无相关性。在浸润性导管癌中，芳香化酶与ER状态呈负相关(P=0.0213)，而在浸润性小叶癌中无相关性。未观察到17个β-HSD-1、芳香酶、PR、ER、临床分期、年龄和Ki67标记指数之间的其他相关性。芳香化酶和17β-HSD在乳腺癌中并不总是同时表达，但在浸润性小叶癌中同时表达比在浸润性导管癌中更常见。因此，这两种酶在人乳腺癌中的表达调控机制可能不同。
The in situ formation of estradiol plays an important role in the development and biological behavior of human breast cancer Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 (17 beta-HSD type 1) are two principal enzymes involved in in situ estradiol production. We evaluated the expression of aromatase and 17 beta-HSD type 1 by immunohistochemistry in 41 cases of invasive breast carcinoma (19 lobular and 22 ductal). We then examined the correlation among the expression of these enzymes, estrogen (ER) and progesterone (PR) receptor status, Ki67 labeling index of carcinoma cells, age, and the clinical stage of the patients. Marked aromatase immunoreactivity was observed in stromal cells around carcinomatous glands in 32 of 41 cases (78%), and 17 beta-HSD type 1 immunoreactivity was detected in carcinoma cells in 23 of 41 cases (56%). There was a significant correlation observed between expression of 17 beta-HSD type 1 and aromatase in invasive lobular carcinoma (P = 0.0119), but not in invasive ductal carcinoma. There was an inverse correlation between aromatase and ER status in invasive ductal carcinoma (P = 0.0213), but not in invasive lobular carcinoma. No other correlations were observed among 17 beta-HSD type 1, aromatase, PR, ER, clinical stage, age, and Ki67 labeling indexes. Aromatase and 17 beta-HSD are not always expressed simultaneously in human breast carcinoma, but their simultaneous expression is more frequent in invasive lobular carcinoma than invasive ductal carcinoma. Consequently, different mechanisms may be involved in the regulation of expression of these two enzymes in human breast carcinoma.