Benign Multiple Sclerosis is Associated with Reduced Thinning of the Retinal Nerve Fiber and Ganglion Cell Layers in Non-Optic-Neuritis Eyes
Benign Multiple Sclerosis is Associated with Reduced Thinning of the Retinal Nerve Fiber and Ganglion Cell Layers in Non-Optic-Neuritis Eyes
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DOI：
10.3988/jcn.2015.11.3.241
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发表时间：
2015-07-01
影响因子：
3.1
通讯作者：
Link, Hans
中科院分区：
文献类型：
--
作者：
Huang-Link, Yu-Min;Fredrikson, Mats;Link, Hans
背景和目的根据临床特征、神经影像学和脑脊液检查，很难区分良性多发性硬化症（BMS）和复发缓解型多发性硬化症（RRMS）。光学相干断层扫描（OCT）可以在微米尺度上量化视网膜结构，如视盘上的视网膜神经纤维层（RNFL）厚度和黄斑处的神经节细胞层（GCL）。它也可以用来追踪微小的改变和神经变性的进展，帮助预测BMS，并影响治疗的选择。利用OCT检测与健康对照（hc）相比，BMS和RRMS患者视盘和黄斑微结构的变化程度，特别关注与视神经炎（on）存在/不存在相关的变化。方法应用光谱域OCT对36例多发性硬化症（MS）患者进行眼部检查，其中BMS 11例，RRMS 25例，hc 34例。结果不论MS类型（即BMS或RRMS），先前受ON影响的眼睛的RNFL和GCL明显比hc薄。与hcc相比，非on RRMS（非on BMS）也观察到GCL明显变薄。相应地，仅在非on RRMS中观察到疾病持续时间与RNFL和GCL变薄率之间的显著关联(-0.54 +/- 0.24和-0.43 +/- 0.21 μ m/年，平均SE； p
Background and Purpose It is exceedingly difficult to differentiate benign multiple sclerosis (BMS) from relapsing-remitting multiple sclerosis (RRMS) based on clinical characteristics, neuroimaging, and cerebrospinal fluid tests. Optical coherence tomography (OCT) allows quantification of retinal structures, such as the retinal nerve fiber layer (RNFL) thickness, at the optic disc and the ganglion cell layer (GCL) at the macula, on a micrometer scale. It can also be used to trace minor alterations and the progression of neurodegeneration, help predict BMS, and influence the choice of therapy. To utilize OCT to detect the extent of changes of the optic disk and macular microstructure in patients with BMS and RRMS compared to healthy controls (HCs), with special focus on changes related to the presence/absence of optic neuritis (ON).Methods Spectral-domain OCT was applied to examine eyes from 36 patients with multiple sclerosis (MS), comprising 11 with BMS and 25 with RRMS, and 34 HCs.Results The RNFL and GCL were significantly thinner in eyes previously affected by ON, irrespective of the type of MS (i.e., BMS or RRMS), than in HCs. Significant thinning of the GCL was also observed in non-ON RRMS (and not non-ON BMS) compared to HCs. Correspondingly, a significant association between disease duration and thinning rates of the RNFL and GCL was observed only in non-ON RRMS (-0.54 +/- 0.24 and -0.43 +/- 0.21 mu m/year, mean SE; p