Prevalence and Correlates of HIV and HCV Infection Among Amphetamine-Type Stimulant Users in 6 Provinces in China
Prevalence and Correlates of HIV and HCV Infection Among Amphetamine-Type Stimulant Users in 6 Provinces in China
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中国6省苯丙胺类兴奋剂使用者HIV和HCV感染状况及相关性
DOI：
10.1097/qai.0b013e31825694f2
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发表时间：
2012-08-01
影响因子：
3.6
通讯作者：
Lu, Lin
中科院分区：
文献类型：
--
作者：
Bao, Yan-Ping;Liu, Zhi-Min;Lu, Lin
背景：近年来，中国出现了苯丙胺类兴奋剂（ATS）滥用的流行。方法：2009年9月至2010年12月，采用多中心横断面研究方法，对我国6个省市的ATS使用者进行HIV和HCV感染状况及相关行为的调查。测量了社会经济/行为风险因素。结果：在1327名ATS使用者中，HIV感染率和HCV暴露率分别为4.5%和43.5%，存在较大的地域差异（分别为0%~ 20.3%和8.6%~ 67.1%）。HIV感染与居住在云南省（调整后的比值比= 15.8; 95%可信区间（CI）：2.0 - 125.1）、多种药物使用独立相关（调整的比值比= 2.6; 95% CI：1.3 - 5.4），性行为频率增加（调整后的比值比= 2.0; 95%CI：1.1 - 4.1），与性传播感染阳性者的性行为史（调整后的比值比= 11.4; 95%CI：1.3 - 98.9）和HCV感染（调整后的比值比= 2.8; 95%CI：1.2 - 6.7）。HCV感染与研究地点、婚姻状况、失业有关（校正比值比= 1.8; 95% CI：1.3 - 2.4）、ATS使用持续时间较长和ATS注射使用史（校正比值比= 13.3; 95%CI：1.5 - 116.1）。HIV感染率在云南省较高，在其他地区较低; HCV感染率在6个省均较高。风险因素强调了对中国这一高危人群采取新的预防策略的必要性。
Background: China has experienced an epidemic of amphetamine-type stimulant (ATS) use in recent years. The present study explored the status and correlates of HIV and hepatitis C virus (HCV) infection among ATS users in China.Methods: A multicenter cross-sectional study of HIV and HCV status and associated behaviors among ATS users was conducted in 6 provinces from September 2009 to December 2010. Socioeconomic/behavioral risk factors were measured. Blood samples were collected to test for HIV and HCV antibodies.Results: Of the 1327 ATS users, the prevalence of HIV and exposure to HCV were 4.5% and 43.5%, respectively, with large geographic variations (0%-20.3% and 8.6%-67.1%, respectively). HIV infection was independently associated with living in Yunnan province [adjusted odds ratio = 15.8; 95% confidence interval (CI): 2.0 to 125.1), polydrug use (adjusted odds ratio = 2.6; 95% CI: 1.3 to 5.4), increased frequency of sexual behavior (adjusted odds ratio = 2.0; 95% CI: 1.1 to 4.1), history of sex with sexually transmitted infection-positive persons (adjusted odds ratio = 11.4; 95% CI: 1.3 to 98.9), and HCV infection (adjusted odds ratio = 2.8; 95% CI: 1.2 to 6.7). HCV was associated with study site, marital status, unemployment (adjusted odds ratio = 1.8; 95% CI: 1.3 to 2.4), a longer duration of ATS use, and history of injection use of ATS (adjusted odds ratio = 13.3; 95% CI: 1.5 to 116.1).Conclusions: The prevalence of HIV was high among ATS users in Yunnan province but quite rare elsewhere, and the prevalence of exposure to HCV was high in 6 provinces. Risk factors emphasize the need for new prevention strategies toward this population at risk in China.