An fMRI study of the interaction of stress and cocaine cues on cocaine craving in cocaine-dependent men
An fMRI study of the interaction of stress and cocaine cues on cocaine craving in cocaine-dependent men
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DOI：
10.1080/10550490701375285
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发表时间：
2007-01-01
影响因子：
3.7
通讯作者：
Kilts, Clint
中科院分区：
文献类型：
--
作者：
Duncan, Erica;Boshoven, William;Kilts, Clint
急性应激与可卡因成瘾的复发有关，可能是通过激活与渴望相关的神经回路。在一项功能磁共振成像研究中，研究了可卡因线索和急性应激的神经反应。10名男性参与者在心理上重新制定了关于可卡因使用的个性化脚本，并在有和没有压力源的情况下（预期电击）进行了中性体验。脚本类型和压力条件之间的相互作用分析显示，更大的激活后扣带皮层和顶叶在可卡因脚本的存在下的压力。这些数据表明，压力可能会通过激活调节奖励处理的大脑区域以及对药物使用提醒的注意力和记忆偏差来加速可卡因成瘾的复发。
Acute stress is associated with relapse in cocaine addiction, possibly through the activation of craving-related neural circuitry. Neural responses to cocaine cues and acute stress were investigated in an fMRI study. Ten male participants mentally reenacted personalized scripts about cocaine use and a neutral experience both with and without a stressor present (anticipation of electrical shock). Interaction analysis between script type and stress condition revealed greater activation of the posterior cingulate cortex and of the parietal lobe during the cocaine script in the presence of the stressor. These data suggest that stress may precipitate relapse in cocaine addiction by activating brain areas that mediate reward processing and the attentional and mnemonic bias for drug use reminders.