Simple lifestyle recommendations and the outcomes of gestational diabetes. A 2x2 factorial randomized trial
Simple lifestyle recommendations and the outcomes of gestational diabetes. A 2x2 factorial randomized trial
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DOI：
10.1111/dom.12289
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发表时间：
2014-10-01
影响因子：
5.8
通讯作者：
Menato, G.
中科院分区：
文献类型：
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作者：
Bo, S.;Rosato, R.;Menato, G.
妊娠期糖尿病（GDM）的运动和行为建议的好处是有争议的。在一项2x2析因设计的随机试验中，我们在200例GDM患者中研究了运动和行为建议对代谢变量和母亲/新生儿结局的影响。所有女性均给予相同的饮食：D组仅接受饮食建议; E组建议每天快走20分钟; B组接受行为饮食建议; BE组与B + E组处方相同。所有组的饮食习惯都有所改善。在多变量回归模型中，空腹血糖没有变化。运动，而不是行为建议，与餐后血糖（p <0.001）、糖化血红蛋白（HbA 1c; p < 0.001）、甘油三酯（p = 0.02）和C反应蛋白（CRP; p < 0.001）的降低相关，并减少任何母亲/新生儿并发症（OR = 0.50; 95%CI=0.28-0.89;p = 0.02）。在GDM患者中，一个简单的运动计划可以降低母体餐后血糖、HbA 1c、CRP、甘油三酯和任何母体/新生儿并发症，但不能降低空腹血糖值。
The benefits of exercise and behavioural recommendations in gestational diabetes mellitus (GDM) are controversial. In a randomized trial with a 2x2 factorial design, we examined the effect of exercise and behavioural recommendations on metabolic variables, and maternal/neonatal outcomes in 200 GDM patients. All women were given the same diet: group D received dietary recommendations only; group E was advised to briskly walk 20-min/day; group B received behavioural dietary recommendations; group BE was prescribed the same as B + E. Dietary habits improved in all groups. In a multivariable regression model, fasting glucose did not change. Exercise, but not behavioural recommendations, was associated with the reduction of postprandial glucose (p < 0001), glycated haemoglobin (HbA1c; p < 0.001), triglycerides (p = 0.02) and C-reactive protein (CRP; p < 0.001) and reduced any maternal/neonatal complications (OR = 0.50; 95%CI=0.28-0.89;p = 0.02). In GDM patients a simple exercise programme reduced maternal postprandial glucose, HbA1c, CRP, triglycerides and any maternal/neonatal complications, but not fasting glucose values.