Cellular resolution imaging of neuronal activity across space and time in the mammalian brain
Cellular resolution imaging of neuronal activity across space and time in the mammalian brain
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DOI：
10.1016/j.cobme.2019.11.004
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发表时间：
2019-12-01
影响因子：
3.9
通讯作者：
Chen, Jerry L.
中科院分区：
文献类型：
--
作者：
Clough, Mitchell;Chen, Jerry L.
长期以来，动作电位一直被认为是大脑中的基本信息，但这些棘波如何编码刺激和驾驶行为的表示仍不清楚。需要大规模的神经元记录，其细胞和尖峰时间分辨率跨越多个大脑区域，以捕捉相关的网络动态，这些动态可以是稀疏的，并分布在整个人群中。这篇综述集中在光学方法的最新进展，这些方法以不断增加的体积、距离、深度和速度推动了同步种群记录的边界。这些技术的整合对于克服在哺乳动物物种中进行全脑成像的基本限制至关重要。
The action potential has long been understood to be the fundamental bit of information in brain, but how these spikes encode representations of stimuli and drive behavior remains unclear. Large-scale neuronal recordings with cellular and spike-time resolution spanning multiple brain regions are needed to capture relevant network dynamics that can be sparse and distributed across the population. This review focuses on recent advancements in optical methods that have pushed the boundaries for simultaneous population recordings at increasing volumes, distances, depths, and speeds. The integration of these technologies will be critical for overcoming fundamental limits in the pursuit of whole brain imaging in mammalian species.