Peripheral Inflammatory Biomarkers and Cognitive Decline in Older Adults With and Without Alzheimer's Disease A Systematic Review
Peripheral Inflammatory Biomarkers and Cognitive Decline in Older Adults With and Without Alzheimer's Disease A Systematic Review
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DOI：
10.3928/00989134-20170519-01
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发表时间：
2017-12-01
影响因子：
1.3
通讯作者：
Yu, Fang
中科院分区：
文献类型：
--
作者：
Li, Danni;Yu, Fang
外周炎症生物标志物可能在老年认知能力下降和阿尔茨海默病（AD）发病率中发挥重要作用;然而，流行病学研究的数据提出了相互矛盾的结果。本综述的目的是系统地确定外周炎症生物标志物与认知能力下降之间相关性的科学现状。使用Medline和Embase数据库检索2006年1月1日至2016年10月28日发表的文章。9项研究符合纳入标准（2项检查了患有AD痴呆的参与者，7项检查了没有痴呆的参与者）。虽然检查了广泛的外周炎症生物标志物，但C反应蛋白和白细胞介素6是研究最多的。研究结果显示，外周炎症生物标志物与认知能力下降之间的关联结果相互矛盾。外周炎症可能会伤害和帮助大脑，因此，调节免疫的挑战将是找到微调炎症的方法来延迟，预防或治疗AD。
Peripheral inflammatory biomarkers may play an important role in the cognitive decline of aging and incidence of Alzheimer's disease (AD); however, data from epidemiological studies present conflicting findings. The purpose of the current review was to systematically determine the current state of the science on the association between peripheral inflammatory biomarkers and cognitive decline. Articles published from January 1, 2006 to October 28, 2016 were searched using the Medline and Embase databases. Nine studies met inclusion criteria (two examined participants with AD dementia and seven examined participants without dementia). Although a wide range of peripheral inflammatory biomarkers was examined, C-reactive protein and interleukin 6 were the most studied. Findings show conflicting results for the association between peripheral inflammatory biomarkers and cognitive decline. Peripheral inflammation may harm and help the brain, and therefore, the challenge of modulating immunity will be to find ways of fine tuning inflammation to delay, prevent, or treat AD.