Insecticide-Treated Plastic Sheeting for Emergency Malaria Prevention and Shelter among Displaced Populations: An Observational Cohort Study in a Refugee Setting in Sierra Leone
Insecticide-Treated Plastic Sheeting for Emergency Malaria Prevention and Shelter among Displaced Populations: An Observational Cohort Study in a Refugee Setting in Sierra Leone
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DOI：
10.4269/ajtmh.2012.11-0744
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发表时间：
2012-08-01
影响因子：
3.3
通讯作者：
Allan, Richard
中科院分区：
文献类型：
--
作者：
Burns, Matthew;Rowland, Mark;Allan, Richard
在两个难民营进行了一项双盲III期疟疾预防试验，使用预先制作的经杀虫剂处理的塑料布（ITPS）或未经处理的聚乙烯布（UPS），随机部署到每个难民营的指定区域。在Largo营地，ITPS或UPS连接在避难所的内壁和天花板上，而在Tobanda， ITPS或UPS仅用于连接天花板和屋顶。在Largo，经8个月的寄生虫清除监测后，3岁以下儿童的恶性疟原虫发病率为UPS组163/100人年，ITPS组63人年（调整优势比[AOR] = 0.40, 95%可信区间[CI] = 0.33-0.47）。在Tobanda， UPS组的发病率为157/100人年，ITPS组为134人年（AOR = 0.85, 95% CI = 0.75-0.95）。全衬ITPS的保护效果为61%，顶衬ITPS的保护效果为15%。在ITPS下，两个营地的贫血率都有所改善。事实证明，这种新工具在紧急情况下用作完整的避难所衬里时，是一种方便、安全、持久的疟疾控制方法。
A double-blind phase III malaria prevention trial was conducted in two refugee camps using pre-manufactured insecticide-treated plastic sheeting (ITPS) or untreated polyethylene sheeting (UPS) randomly deployed to defined sectors of each camp. In Largo camp the ITPS or UPS was attached to inner walls and ceilings of shelters, whereas in Tobanda the ITPS or UPS was used to line only the ceiling and roof. In Largo the Plasmodium falciparum incidence rate in children up to 3 years of age who were cleared of parasites and monitored for 8 months was 163/100 person-years under UPS and 63 under ITPS (adjusted odds ratio [AOR] = 0.40, 95% confidence interval [CI] = 0.33-0.47). In Tobanda incidence was 157/100 person-years under UPS and 134 under ITPS (AOR = 0.85, 95% CI = 0.75-0.95). Protective efficacy was 61% under fully lined ITPS and 15% under roof lined ITPS. Anemia rates improved under ITPS in both camps. This novel tool proved to be a convenient, safe, and long-lasting method of malaria control when used as a full shelter lining in an emergency setting.