Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
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DOI：
10.1126/sciadv.aav3058
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发表时间：
2019-05-01
期刊：
影响因子：
13.6
通讯作者：
Horsnell, William G. C.
中科院分区：
文献类型：
--
作者：
Darby, Matthew G.;Chetty, Alisha;Horsnell, William G. C.
母亲的免疫转移是最重要的保护来源，从生命早期的感染，但母亲的免疫转移是否永久性地改变后代的免疫力的护理知之甚少。在这里，我们确定了母亲谁有孕前寄生虫感染的母亲养育的后代的母亲免疫印迹。由接触蠕虫的母亲喂养幼仔，可将保护性细胞免疫转移给这些后代，使其免受蠕虫感染。加强感染控制不依赖于母源抗体。与T辅助细胞2（T（H）2）中保护性2型免疫系统发育相关的保护作用损害了IL-4 R α（-/-）后代。这种母体获得性免疫维持到成熟，并需要转移（通过护理）到后代的母体来源的T（H）2-感受态CD 4 T细胞。因此，我们的数据表明，母亲在怀孕前暴露于全球流行的感染源，为后代提供了长期的护理获得性免疫益处，由母体来源的病原体经历的淋巴细胞介导。
Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (T(H)2) impaired IL-4R alpha(-/-) off-spring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived T(H)2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.