Clickable Janus Particles
Clickable Janus Particles
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DOI：
10.1021/jacs.6b05633
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发表时间：
2016-09-14
影响因子：
15
通讯作者：
Lee, Daeyeon
中科院分区：
文献类型：
--
作者：
Bradley, Laura C.;Stebe, Kathleen J.;Lee, Daeyeon
Janus粒子是分子两亲性的胶体类似物，可以自组装形成不同的超结构，在适当的催化反应下表现出运动性，并强烈吸附在流体界面上以稳定多相流体混合物。Janus粒子的化学性质是控制其作为胶体表面活性剂在本体溶液和流体界面上的行为和用途的基本参数。为了能够广泛地利用它们，非常需要可扩展的方法来合成具有不同化学成分和形状的Janus粒子。在这里，我们开发了可点击的Janus粒子，可以通过与商业上可获得的硫醇进行硫醇-yne点击反应进行修饰。Janus粒子通过引入羧基、羟基或胺部分而被修饰为两亲性。我们还证明，通过调节改性的程度可以控制粒子的形态，从而控制稳定的乳液类型，并通过连续的点击反应来制备复合Janus粒子。通过硫醇-炔点击化学修饰Janus粒子为制备各种Janus粒子提供了一种快速反应、可扩展的合成方法。
Janus particles are colloidal analogues of molecular amphiphiles that can self-assemble to form diverse suprastructures, exhibit motility under appropriate catalytic reactions, and strongly adsorb to fluid fluid interfaces to stabilize multiphasic fluid mixtures. The chemistry of Janus particles is the fundamental parameter that controls their behavior and utility as colloid surfactants in bulk solution and at fluid interfaces. To enable their widespread utilization, scalable methods that allow for the synthesis of Janus particles with diverse chemical compositions and shapes are highly desirable. Here, we develop clickable Janus particles that can be modified through thiol-yne click reactions with commercially available thiols. Janus particles are modified to be amphiphilic by introducing either carboxyl, hydroxyl, or amine moieties. We also demonstrate that regulating the extent of the modification can be used to control the particle morphology, and thus the type of emulsion stabilized, as, well as to fabricate composite Janus particles through sequential click reactions. Modifying Janus particles through thiol-yne click chemistry provides a fast-reacting, scalable synthesis method for the fabrication of diverse Janus particles.