Enantioselective synthesis of quaternary alpha-aminophosphonates by Pd-catalyzed arylation of cyclic alpha-ketiminophosphonates with arylboronic acids
Enantioselective synthesis of quaternary alpha-aminophosphonates by Pd-catalyzed arylation of cyclic alpha-ketiminophosphonates with arylboronic acids
复制标题
通过 Pd 催化环 α-酮亚氨基膦酸酯与芳基硼酸的芳基化对映选择性合成季 α-氨基膦酸酯
DOI：
10.1039/c6cc04096a
复制
发表时间：
2016
影响因子：
4.9
通讯作者：
Zhou Yong-Gui
中科院分区：
文献类型：
--
作者：
Yan Zhong;Wu Bo;Gao Xiang;Zhou Yong-Gui
报道了手性膦基恶唑啉钯催化芳基硼酸与环状α-酮亚胺膦酸酯的高对映选择性加成反应，提供了一条高效简便的合成α-氨基膦酸季铵盐的路线，收率高，对映选择性高达99.9%。
A highly enantioselective addition of arylboronic acids to cyclic α-ketiminophosphonates is reported using a chiral palladium phosphinooxazoline catalyst, providing an efficient and facile route to quaternary α-aminophosphonates in high yields and up to 99.9% enantioselectivity.