Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis
Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis
复制标题
DOI：
10.1093/gerona/glx096
复制
发表时间：
2018-01-01
影响因子：
5.1
通讯作者：
Kraus, William E.
中科院分区：
文献类型：
--
作者：
Belsky, Daniel W.;Huffman, Kim M.;Kraus, William E.
在旨在减缓衰老的老年保护疗法的试验中，已经提出了生物衰老措施作为延长健康寿命的代理。测量生物衰老的几种方法显示出希望，但尚不清楚这些方法是否对老年保护治疗引起的变化敏感。我们进行了分析的两个建议的方法来量化生物老化的数据，从最近结束的试验，一个既定的老年保护，热量限制。我们从国家老龄化研究所CALERIE随机试验通过其公共访问生物库（https：//calerie.duke.edu/）获得数据。CALERIE试验将N = 220名非肥胖成人随机分为25%热量限制组（n = 145;平均达到11.7%热量限制）或维持当前饮食（n = 75）2年。我们分析了在基线、12个月和24个月随访评估时收集的生物标志物数据。我们将已发表的生物标志物算法应用于这些数据，以计算两种生物年龄指标，Klemera-Doubal方法生物年龄和稳态失调。使用随时间变化的人内变化的混合效应生长模型进行意向治疗分析，如果热量限制减缓了随访期间生物老化指标的增加，则进行测试。对这两项指标的分析表明，热量限制减缓了生物衰老。体重减轻不能解释观察到的效应。研究结果为人类老年保护疗法的测试提供了未来的方向。
Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise but it is not known if these methods are sensitive to changes caused by geroprotective therapy. We conducted analysis of two proposed methods to quantify biological aging using data from a recently concluded trial of an established geroprotector, caloric restriction. We obtained data from the National Institute on Aging CALERIE randomized trial through its public-access biobank (https://calerie.duke.edu/). The CALERIE trial randomized N = 220 nonobese adults to 25% caloric restriction (n = 145; 11.7% caloric restriction was achieved, on average) or to maintain current diet (n = 75) for 2 years. We analyzed biomarker data collected at baseline, 12-, and 24-month follow-up assessments. We applied published biomarker algorithms to these data to calculate two biological age measures, Klemera-Doubal Method Biological Age and homeostatic dysregulation. Intent-to-treat analysis using mixed-effects growth models of within-person change over time tested if caloric restriction slowed increase in measures of biological aging across follow-up. Analyses of both measures indicated caloric restriction slowed biological aging. Weight loss did not account for the observed effects. Results suggest future directions for testing of geroprotective therapies in humans.