HLA class II genes determine the natural variance of hepatitis C viral load
HLA class II genes determine the natural variance of hepatitis C viral load
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DOI：
10.1053/jhep.2001.20642
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发表时间：
2001-01-01
期刊：
影响因子：
13.5
通讯作者：
Shanahan, F
中科院分区：
文献类型：
--
作者：
Fanning, LJ;Levis, J;Shanahan, F
本研究的目的是探讨人类白细胞抗原（HLA）II类基因和丙型肝炎病毒载量的自然波动在一个同质的患者人群之间的关系。研究组包括57例病毒血症（丙型肝炎病毒[HCV] 1b）妇女，其HLA II类DRB 1和DQB 1单倍型，病毒学，组织学和疾病活动的生化标志物可用。1977年5月至1978年11月间，所有患者均感染了丙型肝炎病毒1b型，其病毒载量变化的平均斜率为0.34（SD +/-0.73）log（10）病毒拷贝/mL/年，与0相比有显著性差异，P < 10（-9）。对病毒载量变化斜率与HLA II类单倍型之间的关系的分析表明，（1）DRB 1 - 15和DRB 1 *0701以及（2）DQB 1 *0602和DQB 1 *0201的等位基因之间的病毒载量变化斜率显著不同，多重比较经Bonferroni校正后，分别为P-c = 0.036和P-c = 0.026。DQB 1 *0501和DQB 1 *0201等位基因在肝活检时的疾病分级和分期方面存在显著差异;分别为P = 0.019，r（s）= 0.64和P = 0.047，r（s）= 0.57。此外，发现DRB 1 *13和DRB 1 *0701之间存在疾病阶段的显著差异，P = 0.031，r（s）=-0.71。我们的研究结果确定了感染HCV基因型Ib的患者中病毒载量变化的斜率与HLA II类单倍型之间的相关性，这表明宿主免疫遗传因素在该同质组中HCV感染中的作用。
The aim of this study was to investigate the relationship between human leukocyte antigen (HLA) class II genes and the natural fluctuations in hepatitis C viral load in a homogeneous patient population. The study group consisted of 57 viremic (hepatitis C virus [HCV] 1b) women for whom HLA class II DRB1 and DQB1 haplotyping, virologic, histologic, and biochemical markers of disease activity were available. All patients were infected with HCV 1b from the same source of hepatitis C-contaminated anti-D immunoglobulin during the period from May 1977 to November 1978, The mean slope of change of viral load was 0.34 (SD +/- 0.73) log(10) viral copies/mL/year, which is significantly different from zero, P < 10(-9). Analysis of the relationship between the slope of change of viral load and HLA class II haplotype indicated a significantly different slope of change of viral load between the alleles of (1) DRB1"15 and DRB1*0701, and (2) DQB1*0602 and DQB1*0201, P-c = .036 and P-c = .026 after Bonferroni correction for multiple comparisons, respectively. Significant differences for grade and stage of disease at liver biopsy were observed for DQB1*0501 and DQB1*0201 alleles; P = .019, r(s) = .64, and P = .047, r(s) = .57, respectively. In addition, significant differences in stage of disease were found to exist between DRB1*13 and DRB1*0701, P = .031, r(s) = -.71. Our results define an association between the slope of change of viral load and HLA class II haplotype in patients infected with genotype Ib of HCV, This suggests a role for host immunogenetic factors in HCV infection in this homogeneous group.